Madhuri Singal

Nanoparticle Induced Inflammatory Signaling in the Lung

Mechanism of Aerosil200 Particulate Induced Inflammatory Gene Expression in Alveolar Epithelial Cells

• Broschiertes Buch

Produktbeschreibung

The cardiorespiratory system is designed to facilitate the exchange of gases, such as oxygen and carbon dioxide, maintain acid-base and electrolyte balance, and serve as an important mechanism for filtering potentially harmful environmental materials. Respiratory exposure to nanoparticles, in an environmental or industrial setting, can induce the expression of inflammatory mediators in various cell types of the lung. The research detailed in this book provides a possible mechanism by which particle-induced signaling in alveolar Type II epithelial cells may occur and suggests that the epithelial cell signaling mechanism initiates and propagates a pro-inflammatory pathway that can lead to pulmonary fibrosis. Pulmonary inflammation, resulting from particulate exposure, is an interesting model in which to study inflammation, dysregulated tissue repair and carcinogenesis. With the advent of nanoparticle technology, in industrial and consumer products, toxicological assessment of Aerosil200 particles may become a standard against which to measure the effects of other nanoparticles.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 232
• Englisch
• ISBN-13: 9783639215526
• ISBN-10: 3639215524
• Artikelnr.: 30886469

Autorenporträt

Dr. Singal manages the Respiratory Science Program at the Research Institute for Fragrance Materials, Inc., in Woodcliff Lake, NJ. In addition to her research, she is an active member of the American Association for Respiratory Care, National Board for Respiratory Care, Society of Toxicology, and American Thoracic Society.