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This dissertation deals with the production of nanostructured organic, inorganic and biopolymer materials using supercritical carbon dioxide. Over the past decade, supercritical fluids (SCFs) have emerged for particle formation due to SCFs adjustable solubility and significantly high diffusivity. Various methods have been developed, which can be classified into two basic processes: (a) rapid expansion of supercritical solutions (RESS) for processing CO2-soluble materials, (b) and supercritical antisolvent (SAS) for processing CO2-insoluble materials. In this work, further developments in both…mehr

Produktbeschreibung
This dissertation deals with the production of nanostructured organic, inorganic and biopolymer materials using supercritical carbon dioxide. Over the past decade, supercritical fluids (SCFs) have emerged for particle formation due to SCFs adjustable solubility and significantly high diffusivity. Various methods have been developed, which can be classified into two basic processes: (a) rapid expansion of supercritical solutions (RESS) for processing CO2-soluble materials, (b) and supercritical antisolvent (SAS) for processing CO2-insoluble materials. In this work, further developments in both the methods have been made to overcome the existing challenges and to achieve new nanostructures. Chitin nanofibers are potentially of use in many biomedical and pharmaceutical applications. But, due to highly crystalline nature, it is very difficult to convert into a nanofibrous form. In this work, a SAS method is used to produce chitin nanofibers of average diameter 84 nm using hexafluoroisopropanol as solvent while preserving the molecular structure of the processed chitin. Using SAS with enhanced mass transfer, hydrocortisone nanoparticles were produced.
Autorenporträt
Ranjit Thakur was born on October 18, 1977. He completed his Bachelors degree in Chemical Engineering from Panjab University, India in the year 1998. After completing BE, he joined Chambal Fertilizers and Chemicals Ltd. in India. Later on, in 2001 he planned to accomplish a Doctor of Philosophy in Chemical Engineering at Auburn University.