NANOPARTICLES FOR THERAPEUTIC APPLICATIONS The main goal of this book is to provide information on theranostic applications of various nanomaterials for different diseases with self-explanatory illustrations and fundamental descriptions of a plethora of properties of molecular traits. The author has written a fascinating book on research topics and fundamentals in the cross-disciplinary area of nanotechnology and bioscience in which she successfully fuses otherwise divergent research topics of this rapidly emerging area. The book deals with the use of nanomaterials for combatting…mehr
The main goal of this book is to provide information on theranostic applications of various nanomaterials for different diseases with self-explanatory illustrations and fundamental descriptions of a plethora of properties of molecular traits.
The author has written a fascinating book on research topics and fundamentals in the cross-disciplinary area of nanotechnology and bioscience in which she successfully fuses otherwise divergent research topics of this rapidly emerging area.
The book deals with the use of nanomaterials for combatting various diseases and disorders of the human body. The three chapters of the first part of this book deal with the areas in which nanotechnology has contributed to nanomedicine. In the second part, different disorders like cancer, neurodegenerative diseases, genetic diseases, infectious diseases, cardiovascular disorders, eye, dentistry, bone, and cartilage-affecting diseases are discussed. In the chapters related to a disease or disorder of a particular organ, a basic brief introduction to them is given as well.
Audience
The book will be read by researchers, scientists, and graduate students in biotechnology, nanotechnology, materials science, and nanomedicine/biomedicine.
Madhuri Sharon, (Retd Director at Reliance Industries), PhD from Leicester University, UK, postdoctoral research from Bolton Institute of Technology U.K., is currently the Director of NSN Research Centre for Nanotechnology & Bionanotechnology and Managing Director of Monad Nanotech as well as Adjunct-Professor University of Mumbai & Professor-Emeritus JJT University, India. She has published more than 130 papers, six books, and 11 patents. Her research focuses on the synthesis, biosynthesis, and application of various nanomaterials (graphene oxide, carbon dots, carbon nanomaterials, and nanometals) in drug delivery.
Inhaltsangabe
Foreword xxi
Preface xxiii
Part I: Nano-Flotillas Traversing in the Vein as Carriers to Deliver Theranostics 1
1 Diagnostic and Therapeutic Systems Using Nanomaterials 3
1.1 Introduction 3
1.2 Nanodiagnostic Agents 4
1.2.1 Bio-Barcode Assay (BCA) 5
1.2.2 Cantilever Beam 5
1.2.3 Carbon Dots/Carbon Quantum Dots 8
1.2.3.1 CD as Bioimaging Agent 9
1.2.3.2 CD as Sensor 10
1.2.4 Carbon Nanotubes (CNTs) 11
1.2.4.1 Diagnostic Equipment Using CNT 13
1.2.5 Dendrimers 26
1.2.5.1 Types of Dendrimers 27
1.2.5.2 Applications of Dendrimers 28
1.2.6 DNA 30
1.2.7 Nanocrystals/Quantum Dots (QDs) 33
1.2.7.1 Applications of Nanocrystals/Quantum Dots (QDs) 34
1.2.8 Nanoparticles as Diagnostic Tool 35
1.2.8.1 Inorganic/Metal Nanoparticles 35
1.2.8.2 Polymeric Nanoparticles (PNPs) 43
1.2.9 Nanorobotics 45
1.2.10 Nanoshells 47
1.2.11 Nanowires 48
1.2.12 Optical Tweezers 48
1.2.13 Serum Albumin 50
1.3 Summary 51
References 51
2 Nano Trojan Horses for Delivery of Peptides and Protein Drugs 57
Roopa Dharmatti
2.1 Introduction 57
2.2 Peptides 58
2.2.1 Cell-Penetrating Peptides 61
2.2.1.1 CPP and NP Surface Conjugation Mechanism 62
2.2.1.2 CPP-NP Conjugates in Cancer 64
2.2.1.3 CPP-NP Conjugates in Inflammation 65
2.2.1.4 CPP-NPs Conjugates in Central Nervous System Disorders 66
2.2.2 Antimicrobial Peptides (AMPs) 66
2.2.2.1 Nanomedicines for Antimicrobial Peptides Delivery 68
2.2.3 Peptide Toxins 70
2.2.3.1 Action Mechanism of Peptide Toxins 71
2.2.3.2 Therapeutic Applications of Peptide Toxins from Various Sources 71
2.2.4 Modifications of Natural Peptides for NP and Drug Design 77
2.3 Role of Nanoparticles in Peptide Drug Delivery 77
2.3.1 Vasoactive Intestinal Peptide (VIP) NPs for Diagnostics and for Controlled and Targeted Drug Delivery 79
2.3.1.1 NPs for VIP Drug Delivery 80
2.3.1.2 Structural Basis for Neuropeptide VIP-Targeted Drug Delivery Aided by Nanotechnology 82
2.4 Protein 85
2.4.1 Protein and Peptide Drug Conjugates 86
2.4.1.1 Protein-Drug Conjugates 86
2.4.1.2 Strategies for Chemical Conjugation 90
2.5 Role of Nanoparticles (NPs) in Protein Drug Delivery 96
2.5.1 Liposomes 96
2.5.2 Nanoparticles (NPs) Made from Polymer 97
2.5.3 Carbon Nanotubes (CNTs) 99
2.5.4 Other Metal Nanoparticles (NPs) 100
2.6 Summary 102
References 102
3 Biomimetic Nanomaterials as Smart Scaffolds for Tissue Regeneration 115
3.1 Introduction 115
3.1.1 Concept of Tissue Engineering (TE) 116
3.1.2 A Brief Look at the Type of Tissue-Specific Stem Cells Being Engineered for Tissue Regeneration 117
3.1.3 Growth Factor 119
3.2 Scaffold 119
3.2.1 Basic Requirements for Scaffold 120
3.2.1.1 Biocompatibility of Scaffold Material 120
3.2.1.2 Biodegradability of Scaffold Material 121
3.2.1.3 Mechanical Properties of Scaffold Material 121
