Nanoscience refers to the science & discipline and nanotechnology refers the applied part of it including the engineering to control, manipulation and structuring the matter at an unimaginably small scale: nano scale. It is a relatively emerging field which has a potential to transform the field of dentistry. It offers novel opportunities for molecular disease imaging and technologically advanced clinical tools for oral therapeutic intervention. Nanotechnology in Periodontics has significant potential to yield new generation of mouthwashes, nanoscale characterization of biocompatible implants, tooth hypersensitivity and plaque management therapies. However, Nanodentistry still faces many significant challenges in realizing its tremendous potential.