Nanotechnology in Medicine

Toxicity and Safety
Herausgegeben:Rai, Mahendra; Patel, Mrunali; Patel, Rashmin

• Gebundenes Buch

Produktbeschreibung

NANOTECHNOLOGY IN MEDICINE

Discover thorough insights into the toxicology of nanomaterials used in medicine

In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare.

The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment.

Nanotechnology in Medicine: Toxicity and Safety also provides readers with:
_ A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization
_ Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles
_ Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications
_ In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine

Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

Produktdetails

• Verlag: Wiley & Sons / Wiley-Blackwell
• Artikelnr. des Verlages: 1W119769860
• 1. Auflage
• Seitenzahl: 448
• Erscheinungstermin: 25. Oktober 2021
• Englisch
• Abmessung: 260mm x 183mm x 29mm
• Gewicht: 1026g
• ISBN-13: 9781119769866
• ISBN-10: 1119769868
• Artikelnr.: 62350238

Autorenporträt

Mahendra Rai, PhD, is Professor in the Department of Biotechnology at Sant Gadge Baba Amravati University, India. Professor Rai has edited more than 60 books and published over 400 research papers and reviews in international peer-reviewed journals. Mrunali Patel, PhD, is Professor at Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India. She has written several book chapters and over 100 research papers, reviews, and technical articles. Her research focuses on nanodrug delivery. Rashmin Patel, PhD, is Professor at Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India. He has written several book chapters and over 100 research papers, reviews, and technical articles. His research is focused on nanoassessment.

Inhaltsangabe

Preface xiii

List of Contributors xv

List of Abbreviations xix

Part I Nanomedicine: Nanotoxicological Insights 1

1 Nanomedicines: Applications and Toxicological Concerns 3
Mrunali Patel, Rashmin Patel, and Mahendra Rai

1.1 Introduction 3

1.2 Nanomedicine's Revolution 9

1.3 Potential Applications of Nanomedicine 10

1.3.1 Diagnosis 10

1.3.2 Drug Delivery 12

1.3.3 Tissue Engineering and Regenerative Medicine 17

1.4 Clinical Translation of Nanomedicine 18

1.5 Nanotoxicological Challenges 19

1.6 Safety Issues and Regulations 22

1.7 Conclusion and Future Perspectives 23

References 24

2 Microbial Biopolymers and Their Derivatives as Nanotechnological Tools for Medicine:
Applications, Advantages, Toxicity, and Safety 29
Paulo Ricardo Franco Marcelino, Fernanda Gonçalves, Nayelen Sayuri Aizawa, Henrique Paiva
Pereira, Talita Martins Lacerda, and Silvio Silvério da Silva

2.1 Introduction 29

2.2 Natural Polymers: Conceptualization, Classifications, and Physicochemical Characteristics 30

2.3 Applications of Biopolymers in Nanoparticles, Nanofibers, and Drug Delivery Systems of Therapeutic Importance 35

2.4 Safety of Microbial Biopolymers Used in Nanoscale-Systems for Therapeutic Applications 38

2.5 Conclusions 40

References 41

Part II Nanoparticles: Toxicity and Safety 47

3 Selenium Nanoparticles: Toxicity and Safety 49
Irina A. Shurygina, Irina S. Trukhan, Nataliya N. Dremina, and Michael G. Shurygin

3.1 Introduction 49

3.2 Selenium Forms 50

3.3 Toxicity of Selenium Nanoparticles 52

3.4 Toxicity Mechanisms 56

3.5 Conclusion 60

References 60

4 Impact of Nanoparticles on Protozoa 67
Daniela Plachá and Josef Jampílek

4.1 Introduction 67

4.1.1 Antiprotozoal Drugs 72

4.2 Nanosystems 74

4.2.1 Preparation and Synthesis of Nanoparticles and Systems 75

4.3 Nanosystems with Effect on Human Parasitic Protozoa 77

4.3.1 Malaria 77

4.3.2 Trypanosomiases 79

4.3.3 Leishmaniasis 81

4.3.4 Toxoplasmosis 87

4.3.5 Cryptosporidium 89

4.3.6 Acanthamoeba 90

4.4 Nanosystems with Effect on Veterinary Parasitic Protozoa 91

4.5 Nanomaterial Toxicity on Beneficial Protozoa 93

4.6 Conclusion 96

Acknowledgment 97

References 97

5 Toxicity of Metallic Nanoparticles: A Pressing Issue 109
Tejal Mehta, Dhaivat Parikh, Kartik Hariharan, Namdev Dhas, and Viral Patel

5.1 Introduction 109

5.2 Toxicity of Metal Nanoparticles and Influence of Physicochemical Properties 110

5.2.1 Toxicity of Copper and Copper Oxide Nanoparticles 110

5.2.2 Toxicity of Gold Nanoparticles 112

5.2.2.1 Physicochemical Factors Influencing AuNPs' Toxicity 112

5.2.3 Toxicity of Silver Nanoparticles 115

5.2.4 Toxicity of Zinc Oxide Nanoparticles 117

5.2.5 Toxicity of Iron Oxide Nanoparticles 118

5.2.6 Physicochemical Properties Affecting Toxicity 119

5.3 Accumulation and Toxicity of Metal-Based Nanoparticles in Various Organs 119

5.4 Conclusion and Future Perspectives 128

Acknowledgment 128

References 128

6 Toxicity, Safety, and Biodistribution of Multifunctional Mesoporous Silica
Nanoparticles 137
Mansi Athalye, Rashmin Patel, and Mrunali Patel

6.1 Introduction 137

6.2 Bioapplicability of Mesoporous Silica Nanoparticles 138

6.3 Biodistribution, Toxi