Our study demonstrated that the Use of human olfactory bulb neural stem cells carried on carbon nanotubes scaffolds (OBNSC/CNT) Expressing nerve growth factor (NGF) can relief the cognitive deficiencies associated with TMT lesions in Alzheimer's (AD) model rat via increased NGF production and proliferation and differentiation NSCs supported on nanotubes with their unique properties to help and support the implanted stem cells resulted in restoring the structure and function of the degenerated tissue.