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National public health institutes (NPHIs) are science-based governmental organizations that serve as a focal point for a country's public health efforts, as well as a critical component of global disease prevention and response systems. Among the better known NPHIs are the United States Centers for Disease Control and Prevention, the United Kingdom Health Protection Agency, and the Chinese Center for Disease Control and Prevention. Typical core functions of NPHIs include surveillance for diseases and injuries, as well as risk factors; epidemiologic investigations of health problems; public health research; and response to public health emergencies.