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Approach to green chemistry is an essential aspect in academic and industrial research laboratories. Recent developments showed that, there are many challenges in environmental awareness and issues of sustainability in the world.So We have developed an operationally simple, inexpensive, one pot ,natural catalyzed synthesis of Chalcone by taking a view of green approach.The Book is divided in to III chapters. Introduction to Chalcones is described in chapter-I.The II chapter deals with review of Literature ,In the III chapter, experimental methods for Natural catalyzed synthesis of Chalcone under solvent free condition are described.The content of this book will be very useful to UG and PG students of any University. It will be beneficial to Scientists and especially in Pharmaceutical industry.We would like to extend our thanks and appreciation to Solapur University and Shivaji University, Kolhapur for Spectral Interpretation.We take opportunity to thank to Principal Dr. L.D. Kadam for providing necessary facilities and encouraging us.Finally, we are Very grateful to LAP LAMBERT Academic publishing , Germany to undertake this assignment and for their good support. AUTHOR