Frank Petersen / René Amstutz (eds.)

Natural Compounds as Drugs, Volume II

Mitarbeit:Jucker, Ernst, Eds.: Petersen, Frank, Amstutz, René

• Gebundenes Buch

Produktbeschreibung

The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.

Produktdetails

• Progress in Drug Research Nr.66
• Verlag: Springer, Basel
• Artikelnr. des Verlages: 12120635
• 2008
• Seitenzahl: 444
• Erscheinungstermin: 13. März 2008
• Englisch
• Abmessung: 241mm x 170mm x 32mm
• Gewicht: 1268g
• ISBN-13: 9783764385941
• ISBN-10: 3764385944
• Artikelnr.: 23313477

Inhaltsangabe

Activation of fungal silent gene clusters: An new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin an innovative cornerstone for anti-malaria therapy.

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Activation of fungal silent gene clusters: A new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs — pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin — an innovative cornerstone for anti-malaria therapy.

Rezensionen

From the reviews:

"This second compilation highlights innovative trends in natural products research. ... provide very diverging aspects from molecular biology to practical questions such as production optimization strategies. ... This well-designed volume provides reviews of constant quality in the important field of modern drug research written by an international crew of experts. ... Figures / schemes (numerous formulas) and tables are useful and well organized. ... I recommend this book to anyone interested in modern drug research. It would best be suited for science and industry libraries." (Eckart Eich, Economic Botany, Vol. 63 (4), 2009)