Natural Products Analysis
Instrumentation, Methods, and Applications
Herausgegeben von Havlicek, Vladimir; Spizek, Jaroslav
Natural Products Analysis
Instrumentation, Methods, and Applications
Herausgegeben von Havlicek, Vladimir; Spizek, Jaroslav
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This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products.
- Applies analytical techniques to natural products research - an area of critical importance to drug discovery - Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics - Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug…mehr
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- Applies analytical techniques to natural products research - an area of critical importance to drug discovery
- Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics
- Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence
- Covers instrumental techniques with enough detail for both current practitioners and beginning researchers
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 624
- Erscheinungstermin: 13. Oktober 2014
- Englisch
- Abmessung: 239mm x 157mm x 38mm
- Gewicht: 1043g
- ISBN-13: 9781118466612
- ISBN-10: 1118466616
- Artikelnr.: 41248526
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 624
- Erscheinungstermin: 13. Oktober 2014
- Englisch
- Abmessung: 239mm x 157mm x 38mm
- Gewicht: 1043g
- ISBN-13: 9781118466612
- ISBN-10: 1118466616
- Artikelnr.: 41248526
Contributors xi
1. Natural Products Analysis: Instrumentation, Methods, and Applications 1
Vladimír Havlíèek and Jaroslav Spí?ek
2. The Need for New Antifungal and Antimalarial Compounds 9
Jaroslav Spí?ek and Arnold L. Demain
3. Emerging Instrumental Methods for Antimicrobial Resistance and Virulence
Testing 25
Plamen A. Demirev
4. Plant and Marine Sources: Biological Activity of Natural Products and
Therapeutic Use 43
Amedeo Amedei and Elena Niccolai
5. Emerging Trends for Stimulating the Discovery of Natural Products 115
Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni, Jason C.
Kwan, and Eric W. Schmidt
6. Advances and Challenges in Optical Molecular Spectroscopy Including
Surface Plasmon Resonance-Based Methods for Bioanalysis 163
Pavel Matìjka, Blanka Vlèková, Lucie Bednárová, and Petr Malon
7. Advanced Techniques for NMR Analysis of Complex Biological Mixtures-From
Simple NMR to Hyphenated Techniques 239
Helena Pelantová, Simona Bártová, and Marek Kuzma
8. Advances in X-Ray Diffraction: Implications to the Pharmaceutical
Industry 285
Alexandr Jegorov and Michal Huák
9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Tool in
Biological Sciences 313
Michaela Vainová Galiová, Jan Havli, and Viktor Kanický
10. Imaging Mass Spectrometry, Metabolism, and New Views of the Microbial
World 349
B. Christopher Hoefler and Paul D. Straight
11. Structural Separations for Natural Product Characterization by Ion
Mobility-Mass Spectrometry: Fundamental Theory to Emerging Applications 397
Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. Ruth McNees, Cody R.
Goodwin, Brian O. Bachmann, and John A. McLean
12. High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and
Polyketide Analysis 433
Rebecca H. Wills, Manuela Tosin, and Peter B. O'Connor
13. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and
Affinity-Based Technologies 475
Evelyn H. Wang and Kevin A. Schug
14. Glycosylated Ribosomally Synthesized Peptide Toxins: Discovery,
Characterization, and Applications 507
Gillian E. Norris and Mark L. Patchett
15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the Chemical
Space of Complex Natural Product Mixtures 545
Constanze Müller, Mourad Harir, Norbert Hertkorn, Basem Kanawati, Dimitrios
Tziotis, and Philippe Schmitt-Kopplin
16. Functional Amyloid Fibrils: Lessons from Microbes 571
Sally L. Gras and Dennis Claessen
Index 601
Contributors xi
1. Natural Products Analysis: Instrumentation, Methods, and Applications 1
Vladimír Havlíèek and Jaroslav Spí?ek
2. The Need for New Antifungal and Antimalarial Compounds 9
Jaroslav Spí?ek and Arnold L. Demain
3. Emerging Instrumental Methods for Antimicrobial Resistance and Virulence
Testing 25
Plamen A. Demirev
4. Plant and Marine Sources: Biological Activity of Natural Products and
Therapeutic Use 43
Amedeo Amedei and Elena Niccolai
5. Emerging Trends for Stimulating the Discovery of Natural Products 115
Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni, Jason C.
Kwan, and Eric W. Schmidt
6. Advances and Challenges in Optical Molecular Spectroscopy Including
Surface Plasmon Resonance-Based Methods for Bioanalysis 163
Pavel Matìjka, Blanka Vlèková, Lucie Bednárová, and Petr Malon
7. Advanced Techniques for NMR Analysis of Complex Biological Mixtures-From
Simple NMR to Hyphenated Techniques 239
Helena Pelantová, Simona Bártová, and Marek Kuzma
8. Advances in X-Ray Diffraction: Implications to the Pharmaceutical
Industry 285
Alexandr Jegorov and Michal Huák
9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Tool in
Biological Sciences 313
Michaela Vainová Galiová, Jan Havli, and Viktor Kanický
10. Imaging Mass Spectrometry, Metabolism, and New Views of the Microbial
World 349
B. Christopher Hoefler and Paul D. Straight
11. Structural Separations for Natural Product Characterization by Ion
Mobility-Mass Spectrometry: Fundamental Theory to Emerging Applications 397
Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. Ruth McNees, Cody R.
Goodwin, Brian O. Bachmann, and John A. McLean
12. High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and
Polyketide Analysis 433
Rebecca H. Wills, Manuela Tosin, and Peter B. O'Connor
13. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and
Affinity-Based Technologies 475
Evelyn H. Wang and Kevin A. Schug
14. Glycosylated Ribosomally Synthesized Peptide Toxins: Discovery,
Characterization, and Applications 507
Gillian E. Norris and Mark L. Patchett
15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the Chemical
Space of Complex Natural Product Mixtures 545
Constanze Müller, Mourad Harir, Norbert Hertkorn, Basem Kanawati, Dimitrios
Tziotis, and Philippe Schmitt-Kopplin
16. Functional Amyloid Fibrils: Lessons from Microbes 571
Sally L. Gras and Dennis Claessen
Index 601