Girish J. Kotwal

Natural Products and Molecular Therapy

First International Conference, Volume 1056
Herausgeber: Kotwal, Girish J; Lahiri, Debomoy K

• Broschiertes Buch

Produktbeschreibung

Although the peoples of all continents and cultures have been using different kinds of natural products for centuries, their mechanisms of action are poorly understood. Interestingly, most of these products "work," and paradoxically we are witnessing a great limitation of existing pharmacological targets and agents for various new diseases, such as HIV, as well as those that affect the growing aged population worldwide. This volume presents research focused on the molecular basis of action of different natural products and their applications to various diseases, including cancer, brain disorders, and infectious diseases. Promising natural therapies are scrutinized and evaluated in an effort to advance rigorous scientific analysis of these products and therapies, including achieving neuroprotection through herbal extracts, plant products, and dietary supplements. The role of antioxidants and free radicals from natural products in health and disease is also explored. The research findings presented in this volume focus on botanical, nutritional, and pharmacological strategies for improving general health and slowing normal aging, and the contributors are scientists recognized for their molecular and mechanistic work in this area. African medicine, traditional Chinese and other east Asian medicines, and ayurvedic medicine are addressed, as are a range of other natural treatments/enhancements in current use. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 520
• Erscheinungstermin: 23. Dezember 2005
• Englisch
• Abmessung: 229mm x 152mm x 28mm
• Gewicht: 745g
• ISBN-13: 9781573315951
• ISBN-10: 1573315958
• Artikelnr.: 23195320

Autorenporträt

Girish J. Kotwal is the author of Natural Products and Molecular Therapy: First International Conference, Volume 1056, published by Wiley.

Inhaltsangabe

Preface (Girish Jayant Kotwal and Debomoy Kumar Lahiri). Introductory Remarks: African Perspective on Natural Products and Molecular Medicine (A D Mbewu). Part I: Allergy
Apoptosis
Inflammation
and Immunomodulators. 1. Vaccinia Virus Complement Control Protein Diminishes Formation of Atherosclerotic Lesions: Complement Is Centrally Involved in Atherosclerotic Disease (Perla Thorbjornsdottir
Ragnhildur Kolka
Eggert Gunnarsson
Slavko H. Bambir
Guðmundur Thorgeirsson
Girish J. Kotwal
and Guðmundur J. Arason). 2. Cytokine Therapy (Antony Cutler and Frank Brombacher). 3. Fighting Food Allergy: Current Approaches (Natalie E. Nieuwenhuizen and Andreas L. Lopata). 4. Parasite Mitochondria as a Target of Chemotherapy: Inhibitory Effect of Licochalcone A on the Plasmodium falciparum Respiratory Chain (Fumika Mi-Ichi
Hiroko Miyadera
Tamaki Kobayashi
Shinzaburo Takamiya
Seiji Waki
Susumu Iwata
Shoji Shibata
and Kiyoshi Kita). 5. Vaccinia Virus Complement Control Protein Ameliorates Collagen-Induced Arthritic Mice (Purushottam Jha
Scott A. Smith
David E. Justus
and Girish J. Kotwal). 6. The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection (Zhouning Zhang
Melissa-Rose Abrahams
Lawrence A. Hunt
Jill Suttles
William Marshall
Debomoy K. Lahiri
and Girish J. Kotwal). 7. The Vaccinia Virus N1L ORF May Encode a Multifunctional Protein Possibly Targeting Different Kinases
One of Which Influences ATP Levels in Vivo (Melissa-Rose Abrahams
Zhouning Zhang
Sufan Chien
Tim Skerns
and Girish J. Kotwal). 8. Curcumin Inhibits the Classical and the Alternate Pathways of Complement Activation (Amod P. Kulkarni
Yohannes T. Ghebremariam
and Girish J. Kotwal). 9. Humanized Recombinant Vaccinia Virus Complement Control Protein (hrVCP) with Three Amino Acid Changes
H98Y
E102K
and E120K Creating an Additional Putative Heparin Binding Site
Is 100-fold More Active Than rVCP in Blocking Both Classical and Alternative Complement Pathways (Yohannes T. Ghebremariam
Odutayo O. Odunuga
Kristen Janse
and Girish J. Kotwal). 10. Intervention Strategies and Agents Mediating the Prevention of Xenorejection (Yohannes T. Ghebremariam
Scott A. Smith
J B Anderson
D Kahn
and Girish J. Kotwal). 11. Hemolytic Uremic Syndrome: An Example of Insufficient Complement Regulation on Self-Tissue (John P. Atkinson
M Kathryn Liszewski
Anna Richards
David Kavanagh
and Elizabeth A. Moulton). Part II: Structural Biology of Natural Proteins. 12. Oligomeric Structure of Nitrilases: Effect of Mutating Interfacial Residues on Activity (B T Sewell
R N Thuku
X Zhang
and M J Benedik). 13. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors (Pierre Redelinghuys
Aloysius T. Nchinda
and Edward D. Sturrock). 14. Opportunities for New Therapies Based on the Natural Regulators of Complement Activation (Eve Brook
Andrew P. Herbert
Huw T. Jenkins
Dinesh C. Soares
and Paul N. Barlow). Part III: Natural Enhancers of Health and Fertility. 15. Arthropod-Derived Protein EV131 Inhibits Histamine Action and Allergic Asthma (Wynne Weston-Davies
Isabelle Couillin
Silvia Schnyder
Bruno Schnyder
Rene Moser
Olga Lissina
Guido C. Paesen
Patricia Nuttall
and Bernhard Ryffel). 16. Histamine Scavenging Attenuates Endotoxin-Induced Acute Lung Injury (Bernhard Ryffel
Isabelle Couillin
Isabelle Maillet
Bruno Schnyder
Guido C. Paesen
Patricia Nuttall
and Wynne Weston-Davies). Part IV: Traditional African
Asian
and Mediterranean. 17. Curcumin: Getting Back to the Roots (Shishir Shishodia
Gautam Sethi
and Bharat B. Aggarwal). 18. Transcription Factor NF-B: A Sensor for Smoke and Stress Signals (Kwang Seok Ahn and Bharat B. Aggarwal). 19. Thiolsulfinate Allicin from Garlic: Inspiration for a New Antimicrobial Agent (Roger Hunter
Mino Caira
and Nashia Stellenboom). 20. Effect of Rhythmic Breathing (Sudarshan Kriya and Pranayam) on Immune Functions and Tobacco Addiction (Vinod Kochupillai
Pratik Kumar
Devinder Singh
Dhiraj Aggarwal
Narendra Bhardwaj
Manisha Bhutani
and Satya N. Das). 21. Mediterranean Diet and Cardiovascular Health (Dario Giugliano and Katherine Esposito). 22. Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats (Maheep Bhatnagar
Siddhraj S. Sisodia
and Rekha Bhatnagar). Part V: Antiviral
Antimicrobial Live Vaccine and Plant Vaccines. 23. Novel Drugs and Vaccines Based on the Structure and Function of HIV Pathogenic Proteins Including Nef (Ahmed A. Azad). 24. Anti-HIV
Anti-Poxvirus
and Anti-SARS Activity of a Nontoxic
Acidic Plant Extract from the Trifollium Species Secomet-V/anti-Vac Suggests That It Contains a Novel Broad-Spectrum Antiviral (Girish J. Kotwal
Jennifer N. Kaczmarek
Steven Leivers
Yohannes T. Ghebremariam
Amod P. Kulkarni
Gabriele Bauer
Corena De Beer
Wolfgang Preiser
and Abdu Rahman Mohamed). 25. In Vitro Mutagenicity Studies of the Antiretrovirals AZT
Didanosine
and 3TC and a Plant Antiviral Extract Secomet-V Derived from the Trifollium Species (Michela Ballardin
Roberto Scarpato
Girish J. Kotwal
and Roberto Barale). 26. Punica granatum (Pomegranate) Juice Provides an HIV-1 Entry Inhibitor and Candidate Topical Microbicide (A Robert Neurath
Nathan Strick
Yun-Yao Li
and Asim K. Debnath). 27. Strategies for Human Papillomavirus Therapeutic Vaccines and Other Therapies Based on the E6 and E7 Oncogenes (V A Govan). Part VI: Cutting Edge Technologies and Delivery System. 28. ProtExTM: A Novel Technology to Display Exogenous Proteins on the Cell Surface for Immunomodulation (Narendra P. Singh
Esma S. Yolcu
Nadir Askenasy
and Haval Shirwan). 29. Development and Evaluation of a Suppository Formulation Containing Lactobacillus and Its Application in Vaginal Diseases (Vinita V. Kale
Rashmi V. Trivedi
Sanjay P. Wate
and Kishor P. Bhusari). 30. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization: Establishment of Proof of Principle in TB Mouse Model (Shreemanta K. Parida
Kris Huygen
Bernhard Ryffel
and Trinad Chakraborty). Part VII: Natural Anticancer Therapy. 31. TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH (Olivier Meurette
Laurence Huc
Amelie Rebillard
Gwenaelle Le Moigne
Dominique Lagadic-Gossmann
and Marie-Therese Dimanche-Boitrel). 32. Cloning and Expression of a Functionally Active Truncated N-Glycosylated KSHV ORF4/KCP/Kaposica in the Methylotrophic Yeast Pichia pastoris (Neuza A. Gomes Pereira
Maria A. Juliano
Adriana K. Carmona
Edward D. Sturrock
and Girish J. Kotwal). 33. Antiesophageal Cancer Activity from Southern African Marine Organisms (Catherine E. Whibley
Robert A. Keyzers
Andrew G. Soper
Michael T. Davies-Coleman
Toufiek Samaai
and Denver T. Hendricks). Part VIII: Neuroprotection. 34. Herbal Complement Inhibitors in the Treatment of Neuroinflammation: Future Strategy for Neuroprotection (Amod P. Kulkarni
Laurie A. Kellaway
and Girish J. Kotwal). 35. Amyloid
Cholinesterase
Melatonin
and Metals and Their Roles in Aging and Neurodegenerative Diseases (Debomoy K. Lahiri
De-Mao Chen
Preeti Lahiri
Steve Bondy
and Nigel H. Greig). 36. Administration of Vaccinia Virus Complement Control Protein Shows Significant Cognitive Improvement in a Mild Injury Model (Nirvana S. Pillay
Laurie A. Kellaway
and Girish J. Kotwal). 37. Novel Peptides of Therapeutic Promise from Indian Conidae (K Hanumae Gowd
V Sabareesh
S Sudarslal
Prathima Iengar
Benjamin Franklin
Antony Fernando
Kalyan Dewan
Mani Ramaswami
Siddhartha P. Sarma
Sujit Sikdar
P Balaram
and K S Krishnan). 38. Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism (Ginkgo Biloba Extract EGb 761 (Anne Eckert
Uta Keil
Isabel Scherping
Susanne Hauptmann
and Walter E. Müller). Part IX: Wound Healing and Laser Therapy. 39. Low Level Laser Therapy (LLLT) as an Effective Therapeutic Modality for Delayed Wound Healing (D Hawkins
N Houreld
and H Abrahamse). Closing Remarks (Manto Tshabalala-Msimang). Index of Contributors.