Although the peoples of all continents and cultures have been using different kinds of natural products for centuries, their mechanisms of action are poorly understood. Interestingly, most of these products "work," and paradoxically we are witnessing a great limitation of existing pharmacological targets and agents for various new diseases, such as HIV, as well as those that affect the growing aged population worldwide. This volume presents research focused on the molecular basis of action of different natural products and their applications to various diseases, including cancer, brain…mehr
Although the peoples of all continents and cultures have been using different kinds of natural products for centuries, their mechanisms of action are poorly understood. Interestingly, most of these products "work," and paradoxically we are witnessing a great limitation of existing pharmacological targets and agents for various new diseases, such as HIV, as well as those that affect the growing aged population worldwide. This volume presents research focused on the molecular basis of action of different natural products and their applications to various diseases, including cancer, brain disorders, and infectious diseases. Promising natural therapies are scrutinized and evaluated in an effort to advance rigorous scientific analysis of these products and therapies, including achieving neuroprotection through herbal extracts, plant products, and dietary supplements. The role of antioxidants and free radicals from natural products in health and disease is also explored. The research findings presented in this volume focus on botanical, nutritional, and pharmacological strategies for improving general health and slowing normal aging, and the contributors are scientists recognized for their molecular and mechanistic work in this area. African medicine, traditional Chinese and other east Asian medicines, and ayurvedic medicine are addressed, as are a range of other natural treatments/enhancements in current use. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Girish J. Kotwal is the author of Natural Products and Molecular Therapy: First International Conference, Volume 1056, published by Wiley.
Inhaltsangabe
Preface (Girish Jayant Kotwal and Debomoy Kumar Lahiri). Introductory Remarks: African Perspective on Natural Products and Molecular Medicine (A D Mbewu). Part I: Allergy Apoptosis Inflammation and Immunomodulators. 1. Vaccinia Virus Complement Control Protein Diminishes Formation of Atherosclerotic Lesions: Complement Is Centrally Involved in Atherosclerotic Disease (Perla Thorbjornsdottir Ragnhildur Kolka Eggert Gunnarsson Slavko H. Bambir Guðmundur Thorgeirsson Girish J. Kotwal and Guðmundur J. Arason). 2. Cytokine Therapy (Antony Cutler and Frank Brombacher). 3. Fighting Food Allergy: Current Approaches (Natalie E. Nieuwenhuizen and Andreas L. Lopata). 4. Parasite Mitochondria as a Target of Chemotherapy: Inhibitory Effect of Licochalcone A on the Plasmodium falciparum Respiratory Chain (Fumika Mi-Ichi Hiroko Miyadera Tamaki Kobayashi Shinzaburo Takamiya Seiji Waki Susumu Iwata Shoji Shibata and Kiyoshi Kita). 5. Vaccinia Virus Complement Control Protein Ameliorates Collagen-Induced Arthritic Mice (Purushottam Jha Scott A. Smith David E. Justus and Girish J. Kotwal). 6. The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection (Zhouning Zhang Melissa-Rose Abrahams Lawrence A. Hunt Jill Suttles William Marshall Debomoy K. Lahiri and Girish J. Kotwal). 7. The Vaccinia Virus N1L ORF May Encode a Multifunctional Protein Possibly Targeting Different Kinases One of Which Influences ATP Levels in Vivo (Melissa-Rose Abrahams Zhouning Zhang Sufan Chien Tim Skerns and Girish J. Kotwal). 8. Curcumin Inhibits the Classical and the Alternate Pathways of Complement Activation (Amod P. Kulkarni Yohannes T. Ghebremariam and Girish J. Kotwal). 9. Humanized Recombinant Vaccinia Virus Complement Control Protein (hrVCP) with Three Amino Acid Changes H98Y E102K and E120K Creating an Additional Putative Heparin Binding Site Is 100-fold More Active Than rVCP in Blocking Both Classical and Alternative Complement Pathways (Yohannes T. Ghebremariam Odutayo O. Odunuga Kristen Janse and Girish J. Kotwal). 10. Intervention Strategies and Agents Mediating the Prevention of Xenorejection (Yohannes T. Ghebremariam Scott A. Smith J B Anderson D Kahn and Girish J. Kotwal). 11. Hemolytic Uremic Syndrome: An Example of Insufficient Complement Regulation on Self-Tissue (John P. Atkinson M Kathryn Liszewski Anna Richards David Kavanagh and Elizabeth A. Moulton). Part II: Structural Biology of Natural Proteins. 12. Oligomeric Structure of Nitrilases: Effect of Mutating Interfacial Residues on Activity (B T Sewell R N Thuku X Zhang and M J Benedik). 13. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors (Pierre Redelinghuys Aloysius T. Nchinda and Edward D. Sturrock). 14. Opportunities for New Therapies Based on the Natural Regulators of Complement Activation (Eve Brook Andrew P. Herbert Huw T. Jenkins Dinesh C. Soares and Paul N. Barlow). Part III: Natural Enhancers of Health and Fertility. 15. Arthropod-Derived Protein EV131 Inhibits Histamine Action and Allergic Asthma (Wynne Weston-Davies Isabelle Couillin Silvia Schnyder Bruno Schnyder Rene Moser Olga Lissina Guido C. Paesen Patricia Nuttall and Bernhard Ryffel). 16. Histamine Scavenging Attenuates Endotoxin-Induced Acute Lung Injury (Bernhard Ryffel Isabelle Couillin Isabelle Maillet Bruno Schnyder Guido C. Paesen Patricia Nuttall and Wynne Weston-Davies). Part IV: Traditional African Asian and Mediterranean. 17. Curcumin: Getting Back to the Roots (Shishir Shishodia Gautam Sethi and Bharat B. Aggarwal). 18. Transcription Factor NF-B: A Sensor for Smoke and Stress Signals (Kwang Seok Ahn and Bharat B. Aggarwal). 19. Thiolsulfinate Allicin from Garlic: Inspiration for a New Antimicrobial Agent (Roger Hunter Mino Caira and Nashia Stellenboom). 20. Effect of Rhythmic Breathing (Sudarshan Kriya and Pranayam) on Immune Functions and Tobacco Addiction (Vinod Kochupillai Pratik Kumar Devinder Singh Dhiraj Aggarwal Narendra Bhardwaj Manisha Bhutani and Satya N. Das). 21. Mediterranean Diet and Cardiovascular Health (Dario Giugliano and Katherine Esposito). 22. Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats (Maheep Bhatnagar Siddhraj S. Sisodia and Rekha Bhatnagar). Part V: Antiviral Antimicrobial Live Vaccine and Plant Vaccines. 23. Novel Drugs and Vaccines Based on the Structure and Function of HIV Pathogenic Proteins Including Nef (Ahmed A. Azad). 24. Anti-HIV Anti-Poxvirus and Anti-SARS Activity of a Nontoxic Acidic Plant Extract from the Trifollium Species Secomet-V/anti-Vac Suggests That It Contains a Novel Broad-Spectrum Antiviral (Girish J. Kotwal Jennifer N. Kaczmarek Steven Leivers Yohannes T. Ghebremariam Amod P. Kulkarni Gabriele Bauer Corena De Beer Wolfgang Preiser and Abdu Rahman Mohamed). 25. In Vitro Mutagenicity Studies of the Antiretrovirals AZT Didanosine and 3TC and a Plant Antiviral Extract Secomet-V Derived from the Trifollium Species (Michela Ballardin Roberto Scarpato Girish J. Kotwal and Roberto Barale). 26. Punica granatum (Pomegranate) Juice Provides an HIV-1 Entry Inhibitor and Candidate Topical Microbicide (A Robert Neurath Nathan Strick Yun-Yao Li and Asim K. Debnath). 27. Strategies for Human Papillomavirus Therapeutic Vaccines and Other Therapies Based on the E6 and E7 Oncogenes (V A Govan). Part VI: Cutting Edge Technologies and Delivery System. 28. ProtExTM: A Novel Technology to Display Exogenous Proteins on the Cell Surface for Immunomodulation (Narendra P. Singh Esma S. Yolcu Nadir Askenasy and Haval Shirwan). 29. Development and Evaluation of a Suppository Formulation Containing Lactobacillus and Its Application in Vaginal Diseases (Vinita V. Kale Rashmi V. Trivedi Sanjay P. Wate and Kishor P. Bhusari). 30. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization: Establishment of Proof of Principle in TB Mouse Model (Shreemanta K. Parida Kris Huygen Bernhard Ryffel and Trinad Chakraborty). Part VII: Natural Anticancer Therapy. 31. TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH (Olivier Meurette Laurence Huc Amelie Rebillard Gwenaelle Le Moigne Dominique Lagadic-Gossmann and Marie-Therese Dimanche-Boitrel). 32. Cloning and Expression of a Functionally Active Truncated N-Glycosylated KSHV ORF4/KCP/Kaposica in the Methylotrophic Yeast Pichia pastoris (Neuza A. Gomes Pereira Maria A. Juliano Adriana K. Carmona Edward D. Sturrock and Girish J. Kotwal). 33. Antiesophageal Cancer Activity from Southern African Marine Organisms (Catherine E. Whibley Robert A. Keyzers Andrew G. Soper Michael T. Davies-Coleman Toufiek Samaai and Denver T. Hendricks). Part VIII: Neuroprotection. 34. Herbal Complement Inhibitors in the Treatment of Neuroinflammation: Future Strategy for Neuroprotection (Amod P. Kulkarni Laurie A. Kellaway and Girish J. Kotwal). 35. Amyloid Cholinesterase Melatonin and Metals and Their Roles in Aging and Neurodegenerative Diseases (Debomoy K. Lahiri De-Mao Chen Preeti Lahiri Steve Bondy and Nigel H. Greig). 36. Administration of Vaccinia Virus Complement Control Protein Shows Significant Cognitive Improvement in a Mild Injury Model (Nirvana S. Pillay Laurie A. Kellaway and Girish J. Kotwal). 37. Novel Peptides of Therapeutic Promise from Indian Conidae (K Hanumae Gowd V Sabareesh S Sudarslal Prathima Iengar Benjamin Franklin Antony Fernando Kalyan Dewan Mani Ramaswami Siddhartha P. Sarma Sujit Sikdar P Balaram and K S Krishnan). 38. Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism (Ginkgo Biloba Extract EGb 761 (Anne Eckert Uta Keil Isabel Scherping Susanne Hauptmann and Walter E. Müller). Part IX: Wound Healing and Laser Therapy. 39. Low Level Laser Therapy (LLLT) as an Effective Therapeutic Modality for Delayed Wound Healing (D Hawkins N Houreld and H Abrahamse). Closing Remarks (Manto Tshabalala-Msimang). Index of Contributors.
Preface (Girish Jayant Kotwal and Debomoy Kumar Lahiri). Introductory Remarks: African Perspective on Natural Products and Molecular Medicine (A D Mbewu). Part I: Allergy Apoptosis Inflammation and Immunomodulators. 1. Vaccinia Virus Complement Control Protein Diminishes Formation of Atherosclerotic Lesions: Complement Is Centrally Involved in Atherosclerotic Disease (Perla Thorbjornsdottir Ragnhildur Kolka Eggert Gunnarsson Slavko H. Bambir Guðmundur Thorgeirsson Girish J. Kotwal and Guðmundur J. Arason). 2. Cytokine Therapy (Antony Cutler and Frank Brombacher). 3. Fighting Food Allergy: Current Approaches (Natalie E. Nieuwenhuizen and Andreas L. Lopata). 4. Parasite Mitochondria as a Target of Chemotherapy: Inhibitory Effect of Licochalcone A on the Plasmodium falciparum Respiratory Chain (Fumika Mi-Ichi Hiroko Miyadera Tamaki Kobayashi Shinzaburo Takamiya Seiji Waki Susumu Iwata Shoji Shibata and Kiyoshi Kita). 5. Vaccinia Virus Complement Control Protein Ameliorates Collagen-Induced Arthritic Mice (Purushottam Jha Scott A. Smith David E. Justus and Girish J. Kotwal). 6. The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection (Zhouning Zhang Melissa-Rose Abrahams Lawrence A. Hunt Jill Suttles William Marshall Debomoy K. Lahiri and Girish J. Kotwal). 7. The Vaccinia Virus N1L ORF May Encode a Multifunctional Protein Possibly Targeting Different Kinases One of Which Influences ATP Levels in Vivo (Melissa-Rose Abrahams Zhouning Zhang Sufan Chien Tim Skerns and Girish J. Kotwal). 8. Curcumin Inhibits the Classical and the Alternate Pathways of Complement Activation (Amod P. Kulkarni Yohannes T. Ghebremariam and Girish J. Kotwal). 9. Humanized Recombinant Vaccinia Virus Complement Control Protein (hrVCP) with Three Amino Acid Changes H98Y E102K and E120K Creating an Additional Putative Heparin Binding Site Is 100-fold More Active Than rVCP in Blocking Both Classical and Alternative Complement Pathways (Yohannes T. Ghebremariam Odutayo O. Odunuga Kristen Janse and Girish J. Kotwal). 10. Intervention Strategies and Agents Mediating the Prevention of Xenorejection (Yohannes T. Ghebremariam Scott A. Smith J B Anderson D Kahn and Girish J. Kotwal). 11. Hemolytic Uremic Syndrome: An Example of Insufficient Complement Regulation on Self-Tissue (John P. Atkinson M Kathryn Liszewski Anna Richards David Kavanagh and Elizabeth A. Moulton). Part II: Structural Biology of Natural Proteins. 12. Oligomeric Structure of Nitrilases: Effect of Mutating Interfacial Residues on Activity (B T Sewell R N Thuku X Zhang and M J Benedik). 13. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors (Pierre Redelinghuys Aloysius T. Nchinda and Edward D. Sturrock). 14. Opportunities for New Therapies Based on the Natural Regulators of Complement Activation (Eve Brook Andrew P. Herbert Huw T. Jenkins Dinesh C. Soares and Paul N. Barlow). Part III: Natural Enhancers of Health and Fertility. 15. Arthropod-Derived Protein EV131 Inhibits Histamine Action and Allergic Asthma (Wynne Weston-Davies Isabelle Couillin Silvia Schnyder Bruno Schnyder Rene Moser Olga Lissina Guido C. Paesen Patricia Nuttall and Bernhard Ryffel). 16. Histamine Scavenging Attenuates Endotoxin-Induced Acute Lung Injury (Bernhard Ryffel Isabelle Couillin Isabelle Maillet Bruno Schnyder Guido C. Paesen Patricia Nuttall and Wynne Weston-Davies). Part IV: Traditional African Asian and Mediterranean. 17. Curcumin: Getting Back to the Roots (Shishir Shishodia Gautam Sethi and Bharat B. Aggarwal). 18. Transcription Factor NF-B: A Sensor for Smoke and Stress Signals (Kwang Seok Ahn and Bharat B. Aggarwal). 19. Thiolsulfinate Allicin from Garlic: Inspiration for a New Antimicrobial Agent (Roger Hunter Mino Caira and Nashia Stellenboom). 20. Effect of Rhythmic Breathing (Sudarshan Kriya and Pranayam) on Immune Functions and Tobacco Addiction (Vinod Kochupillai Pratik Kumar Devinder Singh Dhiraj Aggarwal Narendra Bhardwaj Manisha Bhutani and Satya N. Das). 21. Mediterranean Diet and Cardiovascular Health (Dario Giugliano and Katherine Esposito). 22. Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats (Maheep Bhatnagar Siddhraj S. Sisodia and Rekha Bhatnagar). Part V: Antiviral Antimicrobial Live Vaccine and Plant Vaccines. 23. Novel Drugs and Vaccines Based on the Structure and Function of HIV Pathogenic Proteins Including Nef (Ahmed A. Azad). 24. Anti-HIV Anti-Poxvirus and Anti-SARS Activity of a Nontoxic Acidic Plant Extract from the Trifollium Species Secomet-V/anti-Vac Suggests That It Contains a Novel Broad-Spectrum Antiviral (Girish J. Kotwal Jennifer N. Kaczmarek Steven Leivers Yohannes T. Ghebremariam Amod P. Kulkarni Gabriele Bauer Corena De Beer Wolfgang Preiser and Abdu Rahman Mohamed). 25. In Vitro Mutagenicity Studies of the Antiretrovirals AZT Didanosine and 3TC and a Plant Antiviral Extract Secomet-V Derived from the Trifollium Species (Michela Ballardin Roberto Scarpato Girish J. Kotwal and Roberto Barale). 26. Punica granatum (Pomegranate) Juice Provides an HIV-1 Entry Inhibitor and Candidate Topical Microbicide (A Robert Neurath Nathan Strick Yun-Yao Li and Asim K. Debnath). 27. Strategies for Human Papillomavirus Therapeutic Vaccines and Other Therapies Based on the E6 and E7 Oncogenes (V A Govan). Part VI: Cutting Edge Technologies and Delivery System. 28. ProtExTM: A Novel Technology to Display Exogenous Proteins on the Cell Surface for Immunomodulation (Narendra P. Singh Esma S. Yolcu Nadir Askenasy and Haval Shirwan). 29. Development and Evaluation of a Suppository Formulation Containing Lactobacillus and Its Application in Vaginal Diseases (Vinita V. Kale Rashmi V. Trivedi Sanjay P. Wate and Kishor P. Bhusari). 30. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization: Establishment of Proof of Principle in TB Mouse Model (Shreemanta K. Parida Kris Huygen Bernhard Ryffel and Trinad Chakraborty). Part VII: Natural Anticancer Therapy. 31. TRAIL (TNF-Related Apoptosis-Inducing Ligand) Induces Necrosis-Like Cell Death in Tumor Cells at Acidic Extracellular pH (Olivier Meurette Laurence Huc Amelie Rebillard Gwenaelle Le Moigne Dominique Lagadic-Gossmann and Marie-Therese Dimanche-Boitrel). 32. Cloning and Expression of a Functionally Active Truncated N-Glycosylated KSHV ORF4/KCP/Kaposica in the Methylotrophic Yeast Pichia pastoris (Neuza A. Gomes Pereira Maria A. Juliano Adriana K. Carmona Edward D. Sturrock and Girish J. Kotwal). 33. Antiesophageal Cancer Activity from Southern African Marine Organisms (Catherine E. Whibley Robert A. Keyzers Andrew G. Soper Michael T. Davies-Coleman Toufiek Samaai and Denver T. Hendricks). Part VIII: Neuroprotection. 34. Herbal Complement Inhibitors in the Treatment of Neuroinflammation: Future Strategy for Neuroprotection (Amod P. Kulkarni Laurie A. Kellaway and Girish J. Kotwal). 35. Amyloid Cholinesterase Melatonin and Metals and Their Roles in Aging and Neurodegenerative Diseases (Debomoy K. Lahiri De-Mao Chen Preeti Lahiri Steve Bondy and Nigel H. Greig). 36. Administration of Vaccinia Virus Complement Control Protein Shows Significant Cognitive Improvement in a Mild Injury Model (Nirvana S. Pillay Laurie A. Kellaway and Girish J. Kotwal). 37. Novel Peptides of Therapeutic Promise from Indian Conidae (K Hanumae Gowd V Sabareesh S Sudarslal Prathima Iengar Benjamin Franklin Antony Fernando Kalyan Dewan Mani Ramaswami Siddhartha P. Sarma Sujit Sikdar P Balaram and K S Krishnan). 38. Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism (Ginkgo Biloba Extract EGb 761 (Anne Eckert Uta Keil Isabel Scherping Susanne Hauptmann and Walter E. Müller). Part IX: Wound Healing and Laser Therapy. 39. Low Level Laser Therapy (LLLT) as an Effective Therapeutic Modality for Delayed Wound Healing (D Hawkins N Houreld and H Abrahamse). Closing Remarks (Manto Tshabalala-Msimang). Index of Contributors.
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