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No doubt exists concerning the economic impact of mycotoxins. The studies evidenced that economic losses occur at all levels of food and feed production, including crop and animal production, processing, and distribution. Even during favorable climatic periods, millions of dollars are lost as a consequence of crop contamination .For all these reasons, prevention, decontamination, and detoxification of mycotoxins have been considered issues of great importance. Studies have never stopped to evaluate the efficacy of the available detoxification methods and to develop recent innovations in this field to reduce the bioavailability of mycotoxins to poultry and farm animals. The present work is one of these attempts which was designed to investigate ;-the effectiveness of using three anti-aflatoxic agents with different mode of actions. When added to AF-contaminated diets singly or in combination. The three agents investigated included; a)-Hydrated sodium calcium aluminosilicate (HSAS)as an adsorbent which demonstrated a high affinity for aflatoxins, b)-Mannan oligosaccharide (Bio-Mos®) as a biological derivative, c)-c)-Radish extract as an antioxidant agent rich in peroxidase enzyme