Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules explains how to test, analyze and profile drug candidates at the in vitro stage (outside the body) so that drug with poor absorption properties can be eliminated early.
Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules explains how to test, analyze and profile drug candidates at the in vitro stage (outside the body) so that drug with poor absorption properties can be eliminated early.
Alex Avdeef, PhD, is CEO and CSO of pION Inc., and has over thirty years of experience in chemical instrumentation and software development. He is an internationally know authority on solution chemistry and is the author of an extensive list of publications.
Inhaltsangabe
From the contents: Preface. Acknowledgments. Definitions. Introduction. Transport Model. Charge State. Partitioning Into Octanol. Partitioning Into Liposomes. Solubility. Permeability. Summary and Some Simple Rules. References. Index.
From the contents: Preface. Acknowledgments. Definitions. Introduction. Transport Model. Charge State. Partitioning Into Octanol. Partitioning Into Liposomes. Solubility. Permeability. Summary and Some Simple Rules. References. Index.
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