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Actinidic archaea has been related to global warming and human diseases especially neoplasm. The growth of endosymbiotic actinidic archaea in relation to climate change and global warming leads to neanderthalisation of the human mind-body system. Neanderthal anthropometry and metabolonomics has been described in neoplasm. This includes the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces neanderthalisation. Actinidic archaeal related cerebellar dominance leads to changes in brain function. This leads to metabolic syndrome x, cancer, autoimmune disease, neurodegeneration and psychiatric diseases.