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Negative-pressure wound therapy has been widely adopted to treat a broad range of acute and chronic wounds. The biggest disadvantage of this procedure is its cost, which remains high and generally unaffordable over prolonged use. In 2007, the University of São Paulo (USP) developed a low-cost NPWT that used a pressure stabilizer device. The history of this therapy, the development of this method inside the University of Sao Paulo and the results of the study comparing this new method with the traditional NPWT is the theme of this book.