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This research monograph describes the ultrastructural alterations of neurons, neuroglial cells, synapses, blood brain barrier and extracellular space of the cerebral cortex in human brain traumatic injuries, congenital hydrocephalus, vascular anomaly, and brain tumors. This systematic neurobiological approach to the study of brain edema study has been carried out using human cortical biopsies taking during neurosurgical treatment, The content of the book summarizes the author experience for more than four decades, and establishes a comparison with experimental brain edema previously published for leading neuroscientist in animal models of brain edema and human brain pathology. New pathological, pathophysiology and chemical aspects are presented concerning the way how every central nervous structure and substructure participate in the mechanisms of brain edema formation and resolution. All current major concepts linking submicroscopic structures and nerve cell metabolism are included. This book emphasizes the importance of electron microscopic research in neurology, neuropathology and neurosurgery for understanding the basic pathogenetic mechanisms of human brain edema.