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The peripheral sensory innervation of the orofacial region may be injured by oral and maxillofacial surgical and general dental procedures (eg: local anesthetic injections, 3rd molar extractions, mandibular osteotomies, dental implants, endodontic procedures, and preprosthetic surgery), trauma (eg: facial fractures) or secondary to pathologic destruction and treatment (eg: oral squamous cell carcinoma, resection).
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