Nerve Injuries are common. This Thesis studied the regeneration of injured nerves within vein grafts. The work was performed in the laboratories of the department of plastic surgery at UT-SouthWestern Medical Center at Dallas TX. The aim of this study was to evaluate the use of a novel extracellular matrix, E-Matrix, on the regeneration of repaired peripheral nerves in animal experimental model. E-matrix is a complex of biological components that enhances cellular growth and proliferation. We tried to compare the effects of E-matrix to those of nerve growth factors on the nerve regeneration.