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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. NESSUS is a general-purpose, probabilistic analysis program that simulates variations and uncertainties in loads, geometry, material behavior and other user-defined inputs to compute probability of failure and probabilistic sensitivity measures of engineered systems. Because NESSUS uses highly efficient and accurate probabilistic analysis methods, probabilistic solutions can be obtained even for extremely large and complex models. The system performance can be hierarchically decomposed into multiple smaller models and/or analytical equations. Once the probabilistic response is quantified, the results can be used to support risk-informed decisions regarding reliability for safety critical and one-of-a-kind systems, and to maintain a level of quality while reducing manufacturing costs for larger quantity products.