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The plasticity of the brain is defined as the brain's capacity to modify and shape itself into a different form, ability to act, and adapt in a certain way with the given experiences. Due to the brain's plasticity to transform as per the environment's need, each new experience acts as a protective reserve for that individual inclined to age-related brain transformations and pathology. It is one of the basic scientific phenomenon behind brain's ability to recover from conditions like stroke, brain injury, spinal cord injury, etc.Physiotherapists have direct and significant role in rehabilitation of such neurological disorders and this book aims to orient and guide them towards basic understanding of principles and implications of neural plasticity for rehabilitative interventions.