Aim of this work is to observe the effect of some plant neurotoxins ,physical factors and geography in presentation of some Relevant Neuropathology like some form of ASL, PD, AD.The geographic diffusion of the ASL/PD in west pacific ( GUAM foci ) , and mutation of SOD 1 and other are interesting facts to be considered to verify the final neurotoxic process .Related to the references presented a global conclusion about the pathogenetic progression of some neurological disease will be produced as instrument for new hypotesys and for the introduction of new innovative therapeutic strategies.
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