Neurodegeneration
The Molecular Pathology of Dementia and Movement Disorders
Herausgegeben von Dickson, Dennis; Weller, Roy O.
Neurodegeneration
The Molecular Pathology of Dementia and Movement Disorders
Herausgegeben von Dickson, Dennis; Weller, Roy O.
- Gebundenes Buch
- Merkliste
- Auf die Merkliste
- Bewerten Bewerten
- Teilen
- Produkt teilen
- Produkterinnerung
- Produkterinnerung
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells…mehr
- A. Neil CrowsonThe Melanocytic Proliferations347,99 €
- Gary C. KanelPathology of Liver Diseases295,99 €
- Gabrijela KocjanCytopathology of the Head and Neck147,99 €
- Mark H. Tuszynski / Jeffrey Kordower (eds.)CNS Regeneration92,99 €
- Arteriovenous and Cavernous Malformations228,99 €
- Critical Care Neurology Part II224,99 €
- Mohamed E. SalamaAtlas of Diagnostic Hematology175,99 €
-
-
-
Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis.
This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
- Produktdetails
- Verlag: Wiley & Sons
- 2. Aufl.
- Seitenzahl: 496
- Erscheinungstermin: 7. November 2011
- Englisch
- Abmessung: 284mm x 222mm x 32mm
- Gewicht: 1738g
- ISBN-13: 9781405196932
- ISBN-10: 1405196939
- Artikelnr.: 33684549
- Verlag: Wiley & Sons
- 2. Aufl.
- Seitenzahl: 496
- Erscheinungstermin: 7. November 2011
- Englisch
- Abmessung: 284mm x 222mm x 32mm
- Gewicht: 1738g
- ISBN-13: 9781405196932
- ISBN-10: 1405196939
- Artikelnr.: 33684549
viii Preface
xii List of Abbreviations
xiii Part 1 Introduction: Basic Mechanisms of Neurodegeneration 1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders
3 Dennis W. Dickson 2 Cell Death and Neurodegeneration
6 Violetta N. Pivtoraiko and Kevin A. Roth 3 Oxidative Stress and Balance in Neurodegenerative Diseases
10 George Perry
Siddhartha Mondragón-Rodríguez
Akihiko Nunomura
Xiongwei Zhu
Paula I. Moreira and Mark A. Smith 4 Protein Aggregation in Neurodegeneration
13 Adriano Aguzzi and Veronika Kana 5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway
18 Lynn Bedford
Robert Layfi eld
Nooshin Rezvani
Simon Paine
James Lowe and R. John Mayer 6 Genetics of Neurodegeneration
22 John Hardy 7 Transgenic Animal Models of Proteinopathies
26 Naruhiko Sahara
Heather Melrose
Simon D'Alton and Jada Lewis Part 2 Alzheimer's Disease and Aging 8 Clinical Aspects of Alzheimer's Disease
39 David Knopman 9 Genetics of Alzheimer's Disease
51 Lars Bertram and Rudolph E. Tanzi 10 Neuropathology of Alzheimer's Disease and its Variants
62 Charles Duyckaerts and Dennis Dickson 11 Amyloid-ß Production
92 Colin L. Masters and Konrad Beyreuther 12 Elimination of Amyloid ß from the Brain
its Failure in Alzheimer's Disease and Implications for Therapy
97 Roy O. Weller
Seth Love and James A.R. Nicoll Part 3 Tauopathies 13 Introduction to the Tauopathies
105 Michel Goedert 14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17
110 Bernardino Ghetti
Zbigniew K. Wszolek
Bradley F. Boeve
Salvatore Spina and Michel Goedert 15 Progressive Supranuclear Palsy and Corticobasal Degeneration
135 Dennis W. Dickson
Jean-Jaques Hauw
Yves Agid and Irene Litvan 16 Pick's Disease
156 David G. Munoz
Huw R. Morris and Martin Rossor 17 Argyrophilic Grain Disease
165 Markus Tolnay and Heiko Braak 18 Parkinsonism-Dementia Complex of Guam
171 Kiyomitsu Oyanagi
Tomoyo Hashimoto and Mineo Yamazaki 19 Postencephalitic Parkinsonism
179 Kurt A. Jellinger Part 4 Synucleinopathies 20 Introduction to a-Synucleinopathies
191 Maria Grazia Spillantini 21 Parkinson's Disease
194 Kurt A. Jellinger 22 Dementia with Lewy Bodies and Parkinson's Disease Dementia
224 Paul G. Ince 23 Lewy Bodies in Conditions other than Disorders of a-Synuclein
238 Coro Paisán-Ruiz
Laura Parkkinen and Tamas Revesz 24 Multiple System Atrophy
242 Janice L. Holton
Andrew J. Lees and Tamas Revesz Part 5 Trinucleotide Repeat Disorders 25 Introduction to Trinucleotide Repeat Diseases
255 H. Brent Clark 26 Huntington's Disease
258 John C. Hedreen and Raymund A.C. Roos 27 Spinocerebellar Ataxias
273 Hidehiro Mizusawa
H. Brent Clark and Arnulf H. Koeppen 28 Friedreich's Ataxia
288 Arnulf H. Koeppen 29 Dentatorubral-pallidoluysian Atrophy
299 Hitoshi Takahashi
Mitsunori Yamada and Shoji Tsuji 30 Spinal and Bulbar Muscular Atrophy
307 Gen Sobue
Hiroaki Adachi and Masahisa Katsuno Part 6 Prion Disorders 31 Introduction to Prion Disorders
315 Adriano Aguzzi and Veronika Kana 32 Sporadic Creutzfeldt-Jakob Disease
322 Herbert Budka
Mark W. Head
James W. Ironside
Pierluigi Gambetti
Piero Parchi and Fabrizio Tagliavini 33 Genetic Creutzfeldt-Jakob Disease
336 Piero Parchi
Pierluigi Gambetti and Sabina Capellari 34 Fatal Familial and Sporadic Insomnia
346 Piero Parchi
Sabina Capellari and Pierluigi Gambetti 35 A New Prion Disease: Protease-Sensitive Prionopathy
350 Pierluigi Gambetti
Gianfranco Puoti
Qingzhong Kong and Wenquan Zou 36 Variant Creutzfeldt-Jakob Disease
354 James W. Ironside
Mark W. Head and Robert G. Will 37 Gerstmann-Sträussler-Scheinker Disease
364 Bernardino Ghetti
Fabrizio Tagliavini
Gabor G. Kovacs and Pedro Piccardo 38 Kuru
378 Catriona Ann McLean 39 Iatrogenic Creutzfeldt-Jakob Disease
381 James W. Ironside
Richard S.G. Knight and Mark W. Head Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease 40 Introduction
389 James Lowe 41 Frontotemporal Lobar Degeneration with TDP-43 Pathology
393 Ian R.A. Mackenzie and Manuela Neumann 42 Neuronal Intermediate Filament Inclusion Disease
404 Nigel J. Cairns 43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions
412 Manuela Neumann and Ian R.A. Mackenzie 44 Amyotrophic Lateral Sclerosis
Primary Lateral Sclerosis and Spinal Muscular Atrophy
418 Michael J. Strong
Tibor Hortobágyi
Koichi Okamoto and Shinsuke Kato Part 8 Other Neurodegenerative Disorders 45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease
437 John E. Duda 46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia
439 Tamas Revesz
Agueda Rostagno
Gordon Plant
Tammaryn Lashley
Blas Frangione
Jorge Ghiso and Janice L. Holton 47 Neurodegeneration with Brain Iron Accumulation
446 John E. Duda and Kurt A. Jellinger 48 Familial Encephalopathy with Neuroserpin Inclusion Bodies
456 Richard L. Davis and George H. Collins 49 Hereditary Ferritinopathies
461 Ruben Vidal
Marie Bernadette Delisle
Olivier Rascol and Bernardino Ghetti Index
467
viii Preface
xii List of Abbreviations
xiii Part 1 Introduction: Basic Mechanisms of Neurodegeneration 1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders
3 Dennis W. Dickson 2 Cell Death and Neurodegeneration
6 Violetta N. Pivtoraiko and Kevin A. Roth 3 Oxidative Stress and Balance in Neurodegenerative Diseases
10 George Perry
Siddhartha Mondragón-Rodríguez
Akihiko Nunomura
Xiongwei Zhu
Paula I. Moreira and Mark A. Smith 4 Protein Aggregation in Neurodegeneration
13 Adriano Aguzzi and Veronika Kana 5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway
18 Lynn Bedford
Robert Layfi eld
Nooshin Rezvani
Simon Paine
James Lowe and R. John Mayer 6 Genetics of Neurodegeneration
22 John Hardy 7 Transgenic Animal Models of Proteinopathies
26 Naruhiko Sahara
Heather Melrose
Simon D'Alton and Jada Lewis Part 2 Alzheimer's Disease and Aging 8 Clinical Aspects of Alzheimer's Disease
39 David Knopman 9 Genetics of Alzheimer's Disease
51 Lars Bertram and Rudolph E. Tanzi 10 Neuropathology of Alzheimer's Disease and its Variants
62 Charles Duyckaerts and Dennis Dickson 11 Amyloid-ß Production
92 Colin L. Masters and Konrad Beyreuther 12 Elimination of Amyloid ß from the Brain
its Failure in Alzheimer's Disease and Implications for Therapy
97 Roy O. Weller
Seth Love and James A.R. Nicoll Part 3 Tauopathies 13 Introduction to the Tauopathies
105 Michel Goedert 14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17
110 Bernardino Ghetti
Zbigniew K. Wszolek
Bradley F. Boeve
Salvatore Spina and Michel Goedert 15 Progressive Supranuclear Palsy and Corticobasal Degeneration
135 Dennis W. Dickson
Jean-Jaques Hauw
Yves Agid and Irene Litvan 16 Pick's Disease
156 David G. Munoz
Huw R. Morris and Martin Rossor 17 Argyrophilic Grain Disease
165 Markus Tolnay and Heiko Braak 18 Parkinsonism-Dementia Complex of Guam
171 Kiyomitsu Oyanagi
Tomoyo Hashimoto and Mineo Yamazaki 19 Postencephalitic Parkinsonism
179 Kurt A. Jellinger Part 4 Synucleinopathies 20 Introduction to a-Synucleinopathies
191 Maria Grazia Spillantini 21 Parkinson's Disease
194 Kurt A. Jellinger 22 Dementia with Lewy Bodies and Parkinson's Disease Dementia
224 Paul G. Ince 23 Lewy Bodies in Conditions other than Disorders of a-Synuclein
238 Coro Paisán-Ruiz
Laura Parkkinen and Tamas Revesz 24 Multiple System Atrophy
242 Janice L. Holton
Andrew J. Lees and Tamas Revesz Part 5 Trinucleotide Repeat Disorders 25 Introduction to Trinucleotide Repeat Diseases
255 H. Brent Clark 26 Huntington's Disease
258 John C. Hedreen and Raymund A.C. Roos 27 Spinocerebellar Ataxias
273 Hidehiro Mizusawa
H. Brent Clark and Arnulf H. Koeppen 28 Friedreich's Ataxia
288 Arnulf H. Koeppen 29 Dentatorubral-pallidoluysian Atrophy
299 Hitoshi Takahashi
Mitsunori Yamada and Shoji Tsuji 30 Spinal and Bulbar Muscular Atrophy
307 Gen Sobue
Hiroaki Adachi and Masahisa Katsuno Part 6 Prion Disorders 31 Introduction to Prion Disorders
315 Adriano Aguzzi and Veronika Kana 32 Sporadic Creutzfeldt-Jakob Disease
322 Herbert Budka
Mark W. Head
James W. Ironside
Pierluigi Gambetti
Piero Parchi and Fabrizio Tagliavini 33 Genetic Creutzfeldt-Jakob Disease
336 Piero Parchi
Pierluigi Gambetti and Sabina Capellari 34 Fatal Familial and Sporadic Insomnia
346 Piero Parchi
Sabina Capellari and Pierluigi Gambetti 35 A New Prion Disease: Protease-Sensitive Prionopathy
350 Pierluigi Gambetti
Gianfranco Puoti
Qingzhong Kong and Wenquan Zou 36 Variant Creutzfeldt-Jakob Disease
354 James W. Ironside
Mark W. Head and Robert G. Will 37 Gerstmann-Sträussler-Scheinker Disease
364 Bernardino Ghetti
Fabrizio Tagliavini
Gabor G. Kovacs and Pedro Piccardo 38 Kuru
378 Catriona Ann McLean 39 Iatrogenic Creutzfeldt-Jakob Disease
381 James W. Ironside
Richard S.G. Knight and Mark W. Head Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease 40 Introduction
389 James Lowe 41 Frontotemporal Lobar Degeneration with TDP-43 Pathology
393 Ian R.A. Mackenzie and Manuela Neumann 42 Neuronal Intermediate Filament Inclusion Disease
404 Nigel J. Cairns 43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions
412 Manuela Neumann and Ian R.A. Mackenzie 44 Amyotrophic Lateral Sclerosis
Primary Lateral Sclerosis and Spinal Muscular Atrophy
418 Michael J. Strong
Tibor Hortobágyi
Koichi Okamoto and Shinsuke Kato Part 8 Other Neurodegenerative Disorders 45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease
437 John E. Duda 46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia
439 Tamas Revesz
Agueda Rostagno
Gordon Plant
Tammaryn Lashley
Blas Frangione
Jorge Ghiso and Janice L. Holton 47 Neurodegeneration with Brain Iron Accumulation
446 John E. Duda and Kurt A. Jellinger 48 Familial Encephalopathy with Neuroserpin Inclusion Bodies
456 Richard L. Davis and George H. Collins 49 Hereditary Ferritinopathies
461 Ruben Vidal
Marie Bernadette Delisle
Olivier Rascol and Bernardino Ghetti Index
467