Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is themain theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai…mehr
Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is themain theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal isto accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Dr. Jeffery Cummings is an internationally recognized leader in clinical trials and drug development for neurodegenerative disorders. His work has been features in major peer-reviewed journals and his books have been influential world-wide. His work has garnered many awards. Dr. Jagan Pillai trained as a medical doctor at the University of Kerala, Trivandrum, India, obtained his PhD from Northwestern University, and pursued Residency in Neurology at the Albert Einstein College of Medicine. Dr. Pillai was closely involved in helping people with memory disorders and cognitive behavioral changes from neurodegenerative diseases. As a young scholar, Dr. Pillai further developed in research in Alzheimer's dementia and Huntington's disease. Dr. Pillai joined the Lou Ruvo Center for Brain Health in January 2012. He now works to help people with cognitive changes from neurological disorders and to develop diagnostic and treatment strategies for people with cognitive difficulties from neurodegenerative diseases.
Inhaltsangabe
* Table of Contents * List of Contributors * 1 Neurodegenerative Diseases: Evolving Unifying Principles * Jeffrey Cummings and Jagan Pillai * 2 Neurodegenerative Diseases as Protein Misfolding Disorders * Tomohiro Nakamura and Stuart A. Lipton * 3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD * Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny * 4 Neuroinflammation and Neurodegenerative Diseases * Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb * 5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding * Jiri Safar * 6 Neuropsychiatric Features Across Neurodegenerative Diseases * Claudia R. Padilla and Mario F. Mendez * 7 Brain Circuits: Pathway for NDD * William Seeley * 8 Fluid Biomarkers Indicative of Neurodegenerative Diseases * Henrik Zetterberg and Jonathan M. Schott * 9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features * Jagan Pillai * 10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms * Lynn M. Bekris and James B. Leverenz * 11 An Epigenetics Perspective on Diseases of the Central Nervous System * Diego Mastroeni * 12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases * Andrew B. Knot and Ella Bossy-Wetzel * 13 Cell Culture and iPS Cells and Neurodegenerative Diseases * Roxana Nat and Andreas Eigentler * 14 Animal Models of Neurodegenerative Diseases * David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla * 15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases * Peng Lei, Scott Ayton, and Ashley I. Bush * 16 Disease modifying therapies in neurodegenerative disorders * Janelle Drouin-Ouellet and Roger A. Barker * 17 Immunotherapy for Neurodegenerative Disorders * David Morgan * 18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles * Jeffrey Cummings and Kate Zhong * 19 Conclusions on Neurodegenerative Disorders: Unifying Principles * Jagan Pillai and Jeffrey Cummings * Index
* Table of Contents * List of Contributors * 1 Neurodegenerative Diseases: Evolving Unifying Principles * Jeffrey Cummings and Jagan Pillai * 2 Neurodegenerative Diseases as Protein Misfolding Disorders * Tomohiro Nakamura and Stuart A. Lipton * 3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD * Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny * 4 Neuroinflammation and Neurodegenerative Diseases * Taylor R. Jay, Shane M. Bemiller, Lee E. Neilson, Paul J. Cheng, and Bruce T. Lamb * 5 Prion Paradigm of Human Neurodegenerative Diseases Caused by Protein Misfolding * Jiri Safar * 6 Neuropsychiatric Features Across Neurodegenerative Diseases * Claudia R. Padilla and Mario F. Mendez * 7 Brain Circuits: Pathway for NDD * William Seeley * 8 Fluid Biomarkers Indicative of Neurodegenerative Diseases * Henrik Zetterberg and Jonathan M. Schott * 9 Predementia Disorders: Neurodegenerative Diseases Predecessor States as Unifying Clinical Features * Jagan Pillai * 10 Genetics of Neurodegenerative Diseases: Sporadic and Autosomal Dominant Forms * Lynn M. Bekris and James B. Leverenz * 11 An Epigenetics Perspective on Diseases of the Central Nervous System * Diego Mastroeni * 12 Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases * Andrew B. Knot and Ella Bossy-Wetzel * 13 Cell Culture and iPS Cells and Neurodegenerative Diseases * Roxana Nat and Andreas Eigentler * 14 Animal Models of Neurodegenerative Diseases * David Baglietto-Vargas, Rahasson R. Ager, Rodrigo Medeiros, and Frank M. LaFerla * 15 Metal-Protein Attenuating Compounds in Neurodegenerative Diseases * Peng Lei, Scott Ayton, and Ashley I. Bush * 16 Disease modifying therapies in neurodegenerative disorders * Janelle Drouin-Ouellet and Roger A. Barker * 17 Immunotherapy for Neurodegenerative Disorders * David Morgan * 18 Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles * Jeffrey Cummings and Kate Zhong * 19 Conclusions on Neurodegenerative Disorders: Unifying Principles * Jagan Pillai and Jeffrey Cummings * Index
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