David Lovejoy

Neuroendocrinology

An Integrated Approach

• Gebundenes Buch

Produktbeschreibung

Neuroendocrinology: An Integrated Approach provides an introduction to neuroendocrinology from a zoological and evolutionary perspective. Clearly structured, the book covers the evolution, development and description of the neuroendocrine system throughout the animal kingdom.

Taking a modern approach to the subject, the text opens with a discussion on the history of neuroendocrinology and the structure of early neuroendocrine systems in primitive animals. The evolution of ancestral neuroendocrine systems is then traced to living species. With this background in place, the physiology of the neuroendocrine circuits regulating metabolism, biorhythms, stress and reproduction across the animal kingdom are examined. The book ends with chapters on how the neuroendocrine system is regulated by pheromones and xenobiotics in the environment.

This book is an invaluable reference for students taking courses in Neuroendocrinology and Endocrinology as well as those who work in Genomics based drug design and biotech companies based on neurohormones.
_ An integrated genes-to-environment approach.
_ Includes profiles sections written by leaders in the field highlighting unusual aspects of neuroendocrine physiology
_ A unique section on the actions of environmental chemicals in neuroendocrine systems of various species.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 416
• Erscheinungstermin: 19. August 2005
• Englisch
• Abmessung: 244mm x 168mm x 28mm
• Gewicht: 915g
• ISBN-13: 9780470844311
• ISBN-10: 0470844310
• Artikelnr.: 13484132

Autorenporträt

Dr. David. A. Lovejoy, Department of Zoology, University of Toronto, Toronto, Ontario, Canada

Inhaltsangabe

Foreword Acknowledgments 1. History of Neuroendocrinology and Neurohormones
Introduction Early history of physiology Renaissance and the growth of
western science Scientific revolution The 19th-century physiology and
medicine Neurosecretion and the hypothalamus-pituitary regulation Chapter
summary 2. Origin of Life and the First Signalling Molecules Introduction
Theories of the evolution of the first cells The first cells The first true
signalling hormones Chapter summary 3. Rise of Metazoans and the
Elaboration of Signalling Systems Introduction Colonialism and
multicellularity The elaboration of hormone pathways Nervous systems and
rudimentary neuroendocrine systems Increase in genetic complexity and the
rise of triploblastic organisms Chapter summary 4. Elaboration of
Neuroendocrine Systems Introduction Elaboration of nervous system and
development of organismal complexity Nervous and neuroendocrine systems in
phylogenetically younger invertebrates Nervous and neuroendocrine systems
in the deuterostomes Peripheral and autonomic nervous systems Blood-brain
barriers Cerebrospinal fluid and the choroid plexus Neurohaemal and
circumventricular organs: Neurovascular interfaces Hypothalamus-pituitary
gland complex Chapter summary 5. Neurohormones and Receptors: Structure,
Function and Co-evolution Introduction Orthology and paralogy Structural
description of non-peptide ligands Peptide and polypeptide signalling
molecules Structure and classes of receptors Receptor-ligand interactions
Receptor-ligand co-evolution Chapter summary 6. Osmoregulation, Metabolism
and Energy Production Introduction Osmoregulation Role of prolactin Feeding
and appetite regulation Neural circuitry associated with feeding Chapter
summary 7. Growth and Development Introduction Growth and the growth
hormone, prolactin, somatolactin superfamily Metamorphosis and development
Sexual differentiation Mechanisms of ageing Chapter summary 8. Biological
Rythms Introduction Origin of biological clocks Circadian rythms Infradian
rythms Clock circuitry in vertebrates The role of melatonin Chapter summary
9. Stress, Arousal and Homeostatic Challenge Introduction Physiology and
behaviour associated with stress Components of the stress-response system.s
Corticotropin-releasing factor superfamily of peptides Proopiomelanocortin
and adrenocorticotrophic hormone Integration of HPA/I components with other
systems Complementary neuroendocrine circuits associated with stress
Chapter summary 10. Reproduction Introduction Selection of sexual
reproduction Regulation of reproduction Gonadotrophin-releasing hormone
Gonadotrophins and their regulation Neuroendocrine regulation of the HPG
axis Pregnancy, parturition and lactation Seasonal reproduction
Reproduction and stress Chapter summary 11. Behaviour, Learning and Memory
Introduction Basic behavioural circuits Memory Motivation: Reward and fear
Stress and the modulation of learning and behaviour Hormonal facilitation
of behaviour Galanin modulation of neurological circuits An integrated
approach to behavioural modulation Neurodegeneration and trauma Chapter
summary 12. Pheromones and Chemo-attractants Introduction Evolution of
pheromones Classification of pheromones Pheromones in invertebrates
Pheromones in vertebrates Physiological actions of vertebrate pheromones
Pheromones in mammals Chapter summary 13. Xenobiotics and Hormone Mimics
Introduction Types of xenobiotics Vertebrate toxins and defences Toxins and
xenobiotics in invertebrates Toxins and hormone mimics in plants Hormone
mimics from anthropogenic sources Chapter summary Glossary References
Index.

Rezensionen

"...every student of this discipline is encouraged to read anddigest the important information included in this well-writtenvolume." ( The Quarterly Review of Biology , June 2006)
"...provides important context for the development ofneuroendocrinology." ( Doody s Health Services )

"A clearly written introduction to neuroendocrinology from azoological and evolutionary perspective." (PediatricEndocrinology Reviews (PER), May 2006)