Monica Frega

Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems

• Gebundenes Buch

Produktbeschreibung

The bookpresents a new, powerful model of neuronal networks, consisting of athree-dimensional neuronal culture in which 3D neuronal networks are coupled tomicro-electrode-arrays (MEAs). It discusses the main advantages of thethree-dimensional system compared to its two-dimensional counterpart, and showsthat the network dynamics, recorded during both spontaneous and stimulatedactivity, differs between the two models, with the 3D system being better ableto emulate the in vivo behaviour of neural networks. The book offers anextensive analysis of the system, from the theoretical background, to itsdesign and applications in neuro-pharmacological studies. Moreover, itincludes a concise yet comprehensive introduction to both 2D and 3D neuronalnetworks coupled to MEAs, and discusses the advantages, limitations andchallenges of their applications as cellular and tissue-like in vitro experimental model systems.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer International Publishing / Springer, Berlin
• Artikelnr. des Verlages: 978-3-319-30236-2
• 1st ed. 2016
• Seitenzahl: 164
• Erscheinungstermin: 10. März 2016
• Englisch
• Abmessung: 241mm x 160mm x 15mm
• Gewicht: 362g
• ISBN-13: 9783319302362
• ISBN-10: 3319302361
• Artikelnr.: 44464522

Inhaltsangabe

Introduction.- Dissociated Neuronal Networks Coupled toMicro-Electrode Arrays Devices.- In Vitro Neuronal Networks.- 3D NeuronalNetworks: State of the Art.- 3D Neuronal Networks Coupled to MEAs.- Neuro-pharmacologicalStudies.- Discussion and Conclusion.- Data Analysis.