Rudy J Castellani, George Perry, Pouya Jamshidi

Neuropathology of Aging and Alzheimer's Disease

• Broschiertes Buch

Produktbeschreibung

Neuropathology of Aging and Alzheimer’s disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology, given recent advances in tissue characterization in aging and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention, based on a collective of many decades on the part of the authors confronting the challenges of both science and neuropathological diagnosis.

Produktdetails

• Verlag: Elsevier Health Sciences
• Seitenzahl: 320
• Erscheinungstermin: 7. April 2025
• Englisch
• ISBN-13: 9780323996518
• ISBN-10: 0323996515
• Artikelnr.: 70984702

Autorenporträt

Dr. Rudolph J. Castellani is a pathologist in Baltimore, Maryland and is affiliated with multiple hospitals in the area, including?West Virginia University Hospitals?and?Davis Medical Center. He received his medical degree from Wayne State University School of Medicine and has been in practice for more than 20 years. He specializes in Pathology, Neuropathology and Anatomic Pathology. He's published hundreds of articles, and has received ~19 honors and awards.

Inhaltsangabe

1. Historical evolution of Alzheimer’s disease and age-related pathology
from Alzheimer forward
2. Introduction to the neuroanatomy of AD
3. Neurohistologic techniques and methodology
4. Plaque pathology
5. Neurofibrillary degeneration
6. Other Alzheimer disease and age-associated pathology - granulovacuolar
degeneration, Hirano bodies, cerebral amyloid angiopathy
7. Consensus efforts for dementia brain interpretation at autopsy
8. Pathology of autosomal dominant Alzheimer’s disease and Down syndrome
9. Aging-related tau - primary age-related tauopathy, aging-related tau
astrogliopathy, argyrophilic grain disease
10. TDP-43 in aging and Alzheimer’s disease
11. Cerebrovascular disease and cognition
12. Challenges with clinicopathological correlation
13. COVID and Alzheimer’s disease
14. Ethical considerations in the neuropathological diagnosis of AD
15. Neuropathology and the so-called amyloid cascade
16. The diagnostic process in neurodegenerative diseases, including ethical
considerations