Neuroprotection and Cerebral Malaria - Bienvenu, Anne-Lise
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There are at least 300 million cases of malaria each year, resulting in more than a million deaths. Cerebral malaria is the most severe complication of malaria especially in young African children. Besides drug resistance, another challenge in the fight against malaria is the protective treatment of the host combined to the conventional antimalarial treatment. This opportunity came with the consideration of cerebral malaria residual case fatality rate of about 20%, despite a timely adequate antimalarial treatment. This work describes the available experimental model of cerebral malaria, the…mehr

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Produktbeschreibung
There are at least 300 million cases of malaria each year, resulting in more than a million deaths. Cerebral malaria is the most severe complication of malaria especially in young African children. Besides drug resistance, another challenge in the fight against malaria is the protective treatment of the host combined to the conventional antimalarial treatment. This opportunity came with the consideration of cerebral malaria residual case fatality rate of about 20%, despite a timely adequate antimalarial treatment. This work describes the available experimental model of cerebral malaria, the place of neuroprotective therapies in this disease and the efficacy of two neuroprotective drugs, recombinant erythropoietin and statins, during experimental cerebral malaria. Last, a proof- of-concept study documented the relevance of neuroprotection during human cerebral malaria in endemic area. This work should give new insights in medical practices. It should be especially useful to clinicians involved in critical care, infectious diseases, or neurological diseases.
Autorenporträt
Anne-Lise Bienvenu received her Pharmacist Doctor degree in 2006 and her PhD in Parasitology and Medical Mycology in 2009 from Lyon University, France. Her scientific interests include malaria and invasive mycosis. She is focusing her research on new therapies and in particular, cytoprotection.