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High Quality Content by WIKIPEDIA articles! The neutral theory of molecular evolution was introduced by Motoo Kimura in the late 1960s and early 1970s. The theory states that the vast majority of evolutionary changes at the molecular level are caused by random drift of selectively neutral mutants. Although the theory was received by some as an argument against Darwin's theory of evolution by natural selection, Kimura maintained, and most modern evolutionary biologists agree, that the two theories are compatible: "The theory does not deny the role of natural selection in determining the course of adaptive evolution" (Kimura, 1986). However, the theory attributes a large role to genetic drift.