Molecular biology and biochemical techniques, the avant-garde of medical research, are now also being used to investigate cardiovascular events. The fifty-one selected contributions in this volume based on the 14th International Society of Heart Research (ISHR) Meeting in 1992 document the discoveries being made at the frontiers of research with cardiac molecular and genetic biology and technology. The contents may be divided into five categories: 1) the process of ischemic myocardial damage in heart failure, 2) biochemical abnormalities in cardiomyopathy, 3) signal transduction in diseased…mehr
Molecular biology and biochemical techniques, the avant-garde of medical research, are now also being used to investigate cardiovascular events. The fifty-one selected contributions in this volume based on the 14th International Society of Heart Research (ISHR) Meeting in 1992 document the discoveries being made at the frontiers of research with cardiac molecular and genetic biology and technology. The contents may be divided into five categories: 1) the process of ischemic myocardial damage in heart failure, 2) biochemical abnormalities in cardiomyopathy, 3) signal transduction in diseased myocardial cells, 4) electrophysiological abnormalities of the failing heart, and 5) recent concepts in drug therapy. The book builds a bridge for the flow of up-to-date information from active veteran researchers to young talented investigators who offer great promise for the future.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
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Inhaltsangabe
I: Ischemic Myocardial Damage.- Postischemic Myocardial Dysfunction (Myocardial "Stunning"): Role of Oxidative Stress.- Degradation of Membrane Phospholipids in the Ischemic and Reperfused Heart.- Protective Effects of Antiarrhythmic Agents on Oxygen-Deficiency-Induced Contractile Dysfunction of Isolated Perfused Hearts.- Ischemic Myocardial Damage.- II: Cardiomyopathy.- Role of Protein Kinase System in the Signal Transduction of Stretch-mediated Myocyte Growth.- Cellular Mechanisms of Left Ventricular Hypertrophy.- PI Response and Calcium Overload in Cardiomyopathic Hamster Heart Cell.- Mitochondrial DNA Mutations in Cardiomyopathy.- Disrupted Microtubule Structure in the Ischemic and Failing Myocardium - The Role of Calcium Overload.- III: Signal Transduction in Myocardial Cells.- GTP-binding Proteins and Bacterial Toxin-catalyzed ADP-ribosylation.- Regulation of the Gs Protein in the Heart.- Alterations in ?-Adrenergic Receptors in Response to Myocardial Ischemia and their Role in Arrhythmogenesis.- Enzyme-Specific Desensitization of Adenylyl Cyclase in Hypertrophied Heart in Monocrotaline-Treated Rats.- A Mechanism of Catecholamine Tolerance in Congestive Heart Failure.- IV: Electrophysiological Abnormalities in Failing Heart.- Regulation of Calcium Slow Channels in Myocardial Cells by Cyclic Nucleotides and Phosphorylation.- Electrophysiological Abnormalities in Cardiac Hypertrophy.- Altered Responsiveness to Humoral Factors in Cardiac Myocytes of Cardiomyopathic Syrian Hamsters.- Stretch-Activated Current in Rabbit Cardiac Myocytes.- V: Drug Therapy of Failing Heart.- Evaluation of Functional Capacity of Patients with Congestive Heart Failure.- Progress of Treatment and Changing Views on the Role of Compensatory Mechanisms in Chronic Heart Failure.-Cardiotonic Drugs, Intracellular Calcium, and Failing Heart.- Myocardial Calcium Sensitivity and Energy Turnover as Modulated by Inorganic Phosphate and EMD 53998, a Novel Inotropic Agent.- VI: Ischemic Heart Disease.- Left Ventricular Diastolic Function in Effort Angina Pectoris.- The Effect of N,N,N-Trimethylsphingosine on Reperfusion Injury.- VII: Signal Transduction.- Possible Prerequisite Morphological Changes Preceeding Cell Damage During Hypoxia-Reoxygenation in Cardiac Myocytes.- Opioid Modulation of Cardiac Sympathetic Nerve Activity of Baroreceptor Reflex in Rats.- VIII: Congestive Heart Failure.- Clinical Efficacy of Flosequinan in Patients with Mild Chronic Heart Failure: a Double-Blind Placebo-Controlled Study.- Clinical Efficacy of Pimobendan for Patients with Chronic Heart Failure - A Dose Finding Study by a Multicenter Double Blind Trial -.- Effect of Lisinopril on Hemodynamics and Cardiac Hypertrophy in Rats with Aortocaval Fistula.- Increased Plasma Lipid Peroxide in Patients with Congestive Heart Failure.- Dopamine Sulfate and the Cardiovascular System.- Systemic Study of the Hemodynamic Effects of Nitroglycerin in Conscious Dogs: New Aspect of Mechanism of its Antianginal Action.- Load Dependence of Systolic and Diastolic LV Function - On-line Recorded in the Isolated Perfused Guinea Pig Heart. Effects of Ouabain, Caffeine, Gallopamil and [Mg++]0.- Different Load Dependence of -dp/dtmax in Rat and Guinea Pig Hearts and the Influence of Ouabain and Caffeine.- Depressed Endothelium-Dependent Vesodilator Response in the Hindquarter Resistance Vessels in Heart Failure Dogs.- Effects of Calcitonin Gene-Related Peptide on Systemic and Regional Hemodynamics in Dogs with Congestive Heart Failure.- Remarkable Improvement in Congestive Heart Failure inVentricular Septal Rupture by Dopexamine Infusion.- Direct Prevention Against Progressive 201TL Perfusion Defects by Captopril Treatment in Patients with Mild to Moderate Heart Failure.- An Optimal Control Strategy for Regulation of Cardiovascular System.- Myocardial Protection with Ryanodine and CoQ10 Against Post-ischemic Reperfusion Injury of Rabbit Heart.- Angiotensin II Potentiates Collagen Synthesis in the Hypertrophied Heart.- Polyphosphoinositide Metabolism in Hypertrophic Rat Heart.- Cardiovascular Effects of SK&F 64139, a PNMT Inhibitor, in Rats.- IX: Left Ventricular Hypertrophy and Myopathy.- Expression of c-fos mRNA by Acute Pressure Overload in Perfused Rat Heart.- Spontaneous Arrhythmias and Heart Rate Variability in Several Models of Cardiac Hypertrophy in Rat: a Holter Monitoring Study.- Does Angiotensin II Accelerate Protein Synthesis in Adult Rat Hearts?.- Stretch Induces Hypertrophic Growth Through Renin-Angiotensin System in Cultured Neonatal Rat Myocytes.- Does Hypertrophic Cardiomyopathy Change into Dilated Cardiomyopathy-Like Features?.- Likage Analyses of Familial Hypertrophic Cardiomyopathy.- Presence of Angiotensinogen and Renin mRNAs and Angiotensinogen Protein in the Human Heart.- Alteration in Cardiac Renin-Angiotensin System in Spontaneously Hypertensive Rats (SHR).- Keyword Index.
I: Ischemic Myocardial Damage.- Postischemic Myocardial Dysfunction (Myocardial "Stunning"): Role of Oxidative Stress.- Degradation of Membrane Phospholipids in the Ischemic and Reperfused Heart.- Protective Effects of Antiarrhythmic Agents on Oxygen-Deficiency-Induced Contractile Dysfunction of Isolated Perfused Hearts.- Ischemic Myocardial Damage.- II: Cardiomyopathy.- Role of Protein Kinase System in the Signal Transduction of Stretch-mediated Myocyte Growth.- Cellular Mechanisms of Left Ventricular Hypertrophy.- PI Response and Calcium Overload in Cardiomyopathic Hamster Heart Cell.- Mitochondrial DNA Mutations in Cardiomyopathy.- Disrupted Microtubule Structure in the Ischemic and Failing Myocardium - The Role of Calcium Overload.- III: Signal Transduction in Myocardial Cells.- GTP-binding Proteins and Bacterial Toxin-catalyzed ADP-ribosylation.- Regulation of the Gs Protein in the Heart.- Alterations in ?-Adrenergic Receptors in Response to Myocardial Ischemia and their Role in Arrhythmogenesis.- Enzyme-Specific Desensitization of Adenylyl Cyclase in Hypertrophied Heart in Monocrotaline-Treated Rats.- A Mechanism of Catecholamine Tolerance in Congestive Heart Failure.- IV: Electrophysiological Abnormalities in Failing Heart.- Regulation of Calcium Slow Channels in Myocardial Cells by Cyclic Nucleotides and Phosphorylation.- Electrophysiological Abnormalities in Cardiac Hypertrophy.- Altered Responsiveness to Humoral Factors in Cardiac Myocytes of Cardiomyopathic Syrian Hamsters.- Stretch-Activated Current in Rabbit Cardiac Myocytes.- V: Drug Therapy of Failing Heart.- Evaluation of Functional Capacity of Patients with Congestive Heart Failure.- Progress of Treatment and Changing Views on the Role of Compensatory Mechanisms in Chronic Heart Failure.-Cardiotonic Drugs, Intracellular Calcium, and Failing Heart.- Myocardial Calcium Sensitivity and Energy Turnover as Modulated by Inorganic Phosphate and EMD 53998, a Novel Inotropic Agent.- VI: Ischemic Heart Disease.- Left Ventricular Diastolic Function in Effort Angina Pectoris.- The Effect of N,N,N-Trimethylsphingosine on Reperfusion Injury.- VII: Signal Transduction.- Possible Prerequisite Morphological Changes Preceeding Cell Damage During Hypoxia-Reoxygenation in Cardiac Myocytes.- Opioid Modulation of Cardiac Sympathetic Nerve Activity of Baroreceptor Reflex in Rats.- VIII: Congestive Heart Failure.- Clinical Efficacy of Flosequinan in Patients with Mild Chronic Heart Failure: a Double-Blind Placebo-Controlled Study.- Clinical Efficacy of Pimobendan for Patients with Chronic Heart Failure - A Dose Finding Study by a Multicenter Double Blind Trial -.- Effect of Lisinopril on Hemodynamics and Cardiac Hypertrophy in Rats with Aortocaval Fistula.- Increased Plasma Lipid Peroxide in Patients with Congestive Heart Failure.- Dopamine Sulfate and the Cardiovascular System.- Systemic Study of the Hemodynamic Effects of Nitroglycerin in Conscious Dogs: New Aspect of Mechanism of its Antianginal Action.- Load Dependence of Systolic and Diastolic LV Function - On-line Recorded in the Isolated Perfused Guinea Pig Heart. Effects of Ouabain, Caffeine, Gallopamil and [Mg++]0.- Different Load Dependence of -dp/dtmax in Rat and Guinea Pig Hearts and the Influence of Ouabain and Caffeine.- Depressed Endothelium-Dependent Vesodilator Response in the Hindquarter Resistance Vessels in Heart Failure Dogs.- Effects of Calcitonin Gene-Related Peptide on Systemic and Regional Hemodynamics in Dogs with Congestive Heart Failure.- Remarkable Improvement in Congestive Heart Failure inVentricular Septal Rupture by Dopexamine Infusion.- Direct Prevention Against Progressive 201TL Perfusion Defects by Captopril Treatment in Patients with Mild to Moderate Heart Failure.- An Optimal Control Strategy for Regulation of Cardiovascular System.- Myocardial Protection with Ryanodine and CoQ10 Against Post-ischemic Reperfusion Injury of Rabbit Heart.- Angiotensin II Potentiates Collagen Synthesis in the Hypertrophied Heart.- Polyphosphoinositide Metabolism in Hypertrophic Rat Heart.- Cardiovascular Effects of SK&F 64139, a PNMT Inhibitor, in Rats.- IX: Left Ventricular Hypertrophy and Myopathy.- Expression of c-fos mRNA by Acute Pressure Overload in Perfused Rat Heart.- Spontaneous Arrhythmias and Heart Rate Variability in Several Models of Cardiac Hypertrophy in Rat: a Holter Monitoring Study.- Does Angiotensin II Accelerate Protein Synthesis in Adult Rat Hearts?.- Stretch Induces Hypertrophic Growth Through Renin-Angiotensin System in Cultured Neonatal Rat Myocytes.- Does Hypertrophic Cardiomyopathy Change into Dilated Cardiomyopathy-Like Features?.- Likage Analyses of Familial Hypertrophic Cardiomyopathy.- Presence of Angiotensinogen and Renin mRNAs and Angiotensinogen Protein in the Human Heart.- Alteration in Cardiac Renin-Angiotensin System in Spontaneously Hypertensive Rats (SHR).- Keyword Index.
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