New Classical Propargylic Rearrangements in Natural Products Synthesis - Marco-Contelles, José;Carmo Carreiras, Maria do
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In this book we highlight the strong synthetic potential and scope of transition metal-catalyzed rearrangement reactions for fully economical and complex carbon-carbon bond forming reactions. The Meyer-Schuster and the Rupe rearrangements are emerging as the methods of choice for the homologation of carbonyl compounds into , -unsaturated aldehydes and ketones, particularly useful for the synthesis of many hindered ketones. The Rautenstrauch-I and Rautenstrauch-II rearrangements of readily propargylic derivatives are very useful reactions for the synthesis of complex cyclopentenones, and…mehr

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Produktbeschreibung
In this book we highlight the strong synthetic potential and scope of transition metal-catalyzed rearrangement reactions for fully economical and complex carbon-carbon bond forming reactions. The Meyer-Schuster and the Rupe rearrangements are emerging as the methods of choice for the homologation of carbonyl compounds into , -unsaturated aldehydes and ketones, particularly useful for the synthesis of many hindered ketones. The Rautenstrauch-I and Rautenstrauch-II rearrangements of readily propargylic derivatives are very useful reactions for the synthesis of complex cyclopentenones, and bicyclo[n.1.0] enol carboxylates in high chemical yields, which proceed under mild reaction conditions with high stereoselectivity, and total transfer of chirality. In the case of Rautenstrauch-II, the basic-methanolysis of the resulting compounds provides bicyclo[n.1.0]ketones, valuable building blocks for the preparation of natural products. A reaction mechanism has been advanced, and confirmed by experimental evidences, which supports the involvement of metallo-carbenes as key species formed through a cyclopropanation event that precedes the 1,2-acyloxy migration.
Autorenporträt
J Marco-Contelles is Senior Research Professor in CSIC, Madrid since 2004. He has developed synthetic methodologies in sugar-nucleoside, free radical and organometallic chemistry (Pauson-Khand, RCM reactions, PtCl2-mediated cycloisomerizations, heterocyclic systems). In 2002 he was bestowed the French-Spanish award of the French Chemical Society.