The objective of this study is to prepare a chemical compounds for cleaning denture from locally available materials. The chemical compounds solutions were (sodium bicarbonate + alum), (sodium bicarbonate + citric acid), (sodium bicarbonate + apple vinegar), (sodium bicarbonate + clear commercial vinegar), (sodium bicarbonate + thyme oil), (saturated salt solution), (clear commercial vinegar), (alum). In addition, in the main study, the effects of the chemical compounds solutions were evaluated on the (color, water Sorption and transverse strength) of heat - cured denture base material. The t-test showed that the highest increase in optical density for the specimens immersed in (alum), (sodium bicarbonate +alum), (sodium bicarbonate + apple vinegar) solutions at 1/2 hr immersion and it increased more at 8 hrs immersion. The conclusions of this study showed that the safest prepared solutions on the denture base material that could be used as denture cleansers are (sodium bicarbonate{7g}+ clear commercial vinegar{5ml}), (sodium bicarbonate {2g} + thyme oil {3.57g}), (saturated salt solution {40g}) at 1/2 hr and 8 hrs of immersion.