New Developments in Biosciences: Their Implications for Laboratory Animal Science
Proceedings of the Third Symposium of the Federation of European Laboratory Animal Science Associations, held in Amsterdam, The Netherlands, 1¿5 June 1987 Herausgegeben:Beynen, Anthonie C.; Solleveld, H. A.
New Developments in Biosciences: Their Implications for Laboratory Animal Science
Proceedings of the Third Symposium of the Federation of European Laboratory Animal Science Associations, held in Amsterdam, The Netherlands, 1¿5 June 1987 Herausgegeben:Beynen, Anthonie C.; Solleveld, H. A.
This volume includes chapters originally presented at the 3rd FELASA Symposium, held in Amsterdam, June 1-5, 1987. Special topics were "Immune Deficiency Syndromes in Man and Animals", "DNA Technology and Laboratory Animal Science", "Interactions of Behaviour, Housing and Welfare", and "Laboratory Animals as Models in Biomedical Research". In addition, there was a great number of presentations concerning other aspects of laboratory animal science. We would like to thank the following persons for organizing the Symposium. Mrs. M.A.G. Kuipers, M.Sc., President FELASA Mrs. V. Baumans, D.V.M.,…mehr
This volume includes chapters originally presented at the 3rd FELASA Symposium, held in Amsterdam, June 1-5, 1987. Special topics were "Immune Deficiency Syndromes in Man and Animals", "DNA Technology and Laboratory Animal Science", "Interactions of Behaviour, Housing and Welfare", and "Laboratory Animals as Models in Biomedical Research". In addition, there was a great number of presentations concerning other aspects of laboratory animal science. We would like to thank the following persons for organizing the Symposium. Mrs. M.A.G. Kuipers, M.Sc., President FELASA Mrs. V. Baumans, D.V.M., Ph.D., Secretary FELASA P. de Vrey, D.V.M., Treasurer Mrs. I. Zaalmink, Organizing and Scientific Secretariat. The editors would also like to express their gratitude to all the participants and authors for their contribution to this succesful symposium. A.C. Beynen, Ph.D., Secretary Scientific Committee H.A. Solleveld, Ph.D., Chairman Scientific Committee FELASA Federation of European Laboratory Animal Science Associations Gesellschaft fUr Versuchstierkunde/Society for Laboratory Animal Science Laboratory Animal Science Association Nederlandse Vereniging voor Proefdierkunde Scandinavian Federation for Laboratory Animal Science Societe Fran9aise d'Experimentation Animale VII CONTENTS Contributors ....................................................... xiii OPENING ADDRESS: THE FUTURE OF LABORATORY ANIMAL USE R.J. Samsom ....................................................... .
Opening Address: The Future of Laboratory Animal Use.- The Acquired Immunedeficiency Syndrome in Man.- Feline Acquired Immunodeficiency Syndromes.- Immune Deficiency Syndrome in Rodents: The Nude Rat.- Animal Welfare - Common Interest.- Laboratory Animal ....... Science - Service - Use.- Laboratory Animal Science in Czechoslovakia.- On the Ethology of Pain, its Experience and Expression.- Pain in Neonates.- Endorphins and Pain.- Effects of Exogenous Pain Relieving Substances on Experimental Results.- Veterinary Care at the Primate Center TNO.- Developing Housing Facilities for Rhesus Monkeys: Prevention of Abnormal Behaviour.- Microbiological Quality Assurance and Quality Assessment of Laboratory Animals.- Centralisation - Decentralisation: Failure - Success.- The Effect of Homogenization and Pasteurization on the Allergenicity of Bovine Milk Analysed by a Murine Anaphylactic Shock Model.- Murine Passive Cutaneous Anaphylaxis Test (PCA) for the "All or None" Determination of Allergenicity of Bovine Whey Proteins and Peptides.- Phenotypic and Patho-Morphological Characteristics in a Half-Sib-Family of Transgenic Mice Carrying Foreign MT-HGH Genes.- The Housing and Handling of Marmosets and Tamarins Infected With Aids and Other Retroviruses.- Long-Term Observation of Litter Intervals in Permanently Monogamous Mated Han:NMRI Mice.- Genital Inflammation in Male Mice. A Microbiological Study.- Microbial Assessment of a Single Fumigation by Formaldehyde of a Multi-Level Animal Facility.- Mechanisms of Natural Selection Maintaining in Groups of Highly Standardized Mice and Rats, Influence on Infection Resistance.- Provocation of Latent Infections.- to Recombinant DNA Technology.- DNA Hybridization as a Tool in Diagnosing Infectious Diseases. Comparison With OtherMethods..- Embryo Transfer and Manipulation.- Strain Preservation of Rodent Embryos. Possibilities and Limitations.- The Generation of Transgenic Animals and Their Use in Fundamental Research.- On the Inheritance of Blood Characters in Mice.- Investigating Genetic Variability Between the MHS Hypertensive Strain of Rats and its Normotensive Control, MNS.- Gene Mapping and Linkage Homology.- A New Method to Produce Artificial Monozygotic Twins in Mice.- Genetic Analysis of Multigenic Traits Using the Recombinant Congenic Strains.- Acute Dermal Toxicity: Morphological Response of the Hairless Mice Skin Organ Culture.- The Dutch Rabbit in Toxicity Testing. Chemical-Induced Creatine Kinase Release; A Species- and Strain-Specific Response?.- Intertrial-Interval in the "Water Escape Test" in Mice.- Behaviour, Housing and Welfare of Non-Human Primates.- Housing and Welfare of Laboratory Rodents.- Housing Conditions and Experimental Results.- Basis of the European Guidelines: Facts or Intuition?.- Gnotobiotic Animals in Nutrition Research.- Animal Models for Cholesterol Metabolism Studies.- Animal Models in Hemostasis and Thrombosis.- Mice with Ulcerating Lesions on the Nose, Limbs and/or Tail.- Spontaneous Hyperplasia of the Endometrium in the Rabbit.- Monkey Graffity: Environmental Deficiency, Boredom or Artistic Drive?.- Marking of African Clawed Toads (Xenopus laevis). Improvement of a Skin Autograft Technique.- Changes in Energy Intake, Body Weight Gains, Average Feed Efficiency and Some Plasma Hormone Levels in Dogs from Different Environments.- Serum Concentrations of Vitamins A, D and E of Growing Beagles Fed Commercial Dog and Fox Diets.- Integration of HGH Gene in Transgenic Mice and Transmission to Next Generation.- Attempts to Produce Transgenic Rabbits CarryingMTI-HGH Recombinant Gene.- Electrofusion of Early Mammalian Embryo Cells.- Passive Infrared Movement Detector, A New Equipment to Monitor Motor Activity of Small Rodents in Normal Cages.- Establishment of a SPF Population of Cricetulus griseus.- Chronic Phlorizin Intoxication in Adipose Mutant Mice C57BL/KS db/db and in Normal Controls.- Plasma ?-Amylase and Lipase Activities in Dogs with Variations in Food Composition and Availability.- Locomotor Activity of a Behavior Mutant in NMRI Mice.- The Application of Embryo Transfer and Cryopreservation to Commercial Laboratory Animal Breeding.- Serological Following of a Laboratory Rat Breeding Contaminated with Respiratory Viruses During 1981-1986.- Eradication of Encephalitozoonosis in Rabbit Breeding Colonies by Carbon Immunoassay.- Spontaneous Murine Hemosiderosis, A Model for Human Hemochromatosis?.- In Vitro Adhesion of K88 Positive E. Coli to Intestinal Villi of Just-Weaned Piglets.- The Effects of Gentling on Open-Field Behaviour of Rats.- Blastomere-Karyotyping: A Direct Method for Producing Mouse Trisomy 16 ? Diploid Aggregation Chimeras as an Animal Model of Human Down's Syndrome.- A Proposed Species Difference in the Renal Excretion of Perfluoro Octanoic Acid in the Beagle Dog and Rat.- Measurement of Orthostatic Responses in Conscious Dogs.- Oral 65Zn Loading Test in Rats FED IRI-OB Diet with Various Zn Concentrations.- Mortality and Tumour Incidence of BDII/Han Rats.- Assessment of Discomfort Induced by Orbital Functure in Rats.- Effect of Morphinomimetics in Different Pain Tests.- Prevention of Early Deaths in Mice Contaminated with Gram Negative Enteric Bacteria and Fungus Following Irradiation.- Detection of Mycoplasma neurolyticum in a Colony of Inbred Mice: Clinically Silent Infection.- Effects ofHandling and Transportation Stress on Rodents.
Opening Address: The Future of Laboratory Animal Use.- The Acquired Immunedeficiency Syndrome in Man.- Feline Acquired Immunodeficiency Syndromes.- Immune Deficiency Syndrome in Rodents: The Nude Rat.- Animal Welfare - Common Interest.- Laboratory Animal ....... Science - Service - Use.- Laboratory Animal Science in Czechoslovakia.- On the Ethology of Pain, its Experience and Expression.- Pain in Neonates.- Endorphins and Pain.- Effects of Exogenous Pain Relieving Substances on Experimental Results.- Veterinary Care at the Primate Center TNO.- Developing Housing Facilities for Rhesus Monkeys: Prevention of Abnormal Behaviour.- Microbiological Quality Assurance and Quality Assessment of Laboratory Animals.- Centralisation - Decentralisation: Failure - Success.- The Effect of Homogenization and Pasteurization on the Allergenicity of Bovine Milk Analysed by a Murine Anaphylactic Shock Model.- Murine Passive Cutaneous Anaphylaxis Test (PCA) for the "All or None" Determination of Allergenicity of Bovine Whey Proteins and Peptides.- Phenotypic and Patho-Morphological Characteristics in a Half-Sib-Family of Transgenic Mice Carrying Foreign MT-HGH Genes.- The Housing and Handling of Marmosets and Tamarins Infected With Aids and Other Retroviruses.- Long-Term Observation of Litter Intervals in Permanently Monogamous Mated Han:NMRI Mice.- Genital Inflammation in Male Mice. A Microbiological Study.- Microbial Assessment of a Single Fumigation by Formaldehyde of a Multi-Level Animal Facility.- Mechanisms of Natural Selection Maintaining in Groups of Highly Standardized Mice and Rats, Influence on Infection Resistance.- Provocation of Latent Infections.- to Recombinant DNA Technology.- DNA Hybridization as a Tool in Diagnosing Infectious Diseases. Comparison With OtherMethods..- Embryo Transfer and Manipulation.- Strain Preservation of Rodent Embryos. Possibilities and Limitations.- The Generation of Transgenic Animals and Their Use in Fundamental Research.- On the Inheritance of Blood Characters in Mice.- Investigating Genetic Variability Between the MHS Hypertensive Strain of Rats and its Normotensive Control, MNS.- Gene Mapping and Linkage Homology.- A New Method to Produce Artificial Monozygotic Twins in Mice.- Genetic Analysis of Multigenic Traits Using the Recombinant Congenic Strains.- Acute Dermal Toxicity: Morphological Response of the Hairless Mice Skin Organ Culture.- The Dutch Rabbit in Toxicity Testing. Chemical-Induced Creatine Kinase Release; A Species- and Strain-Specific Response?.- Intertrial-Interval in the "Water Escape Test" in Mice.- Behaviour, Housing and Welfare of Non-Human Primates.- Housing and Welfare of Laboratory Rodents.- Housing Conditions and Experimental Results.- Basis of the European Guidelines: Facts or Intuition?.- Gnotobiotic Animals in Nutrition Research.- Animal Models for Cholesterol Metabolism Studies.- Animal Models in Hemostasis and Thrombosis.- Mice with Ulcerating Lesions on the Nose, Limbs and/or Tail.- Spontaneous Hyperplasia of the Endometrium in the Rabbit.- Monkey Graffity: Environmental Deficiency, Boredom or Artistic Drive?.- Marking of African Clawed Toads (Xenopus laevis). Improvement of a Skin Autograft Technique.- Changes in Energy Intake, Body Weight Gains, Average Feed Efficiency and Some Plasma Hormone Levels in Dogs from Different Environments.- Serum Concentrations of Vitamins A, D and E of Growing Beagles Fed Commercial Dog and Fox Diets.- Integration of HGH Gene in Transgenic Mice and Transmission to Next Generation.- Attempts to Produce Transgenic Rabbits CarryingMTI-HGH Recombinant Gene.- Electrofusion of Early Mammalian Embryo Cells.- Passive Infrared Movement Detector, A New Equipment to Monitor Motor Activity of Small Rodents in Normal Cages.- Establishment of a SPF Population of Cricetulus griseus.- Chronic Phlorizin Intoxication in Adipose Mutant Mice C57BL/KS db/db and in Normal Controls.- Plasma ?-Amylase and Lipase Activities in Dogs with Variations in Food Composition and Availability.- Locomotor Activity of a Behavior Mutant in NMRI Mice.- The Application of Embryo Transfer and Cryopreservation to Commercial Laboratory Animal Breeding.- Serological Following of a Laboratory Rat Breeding Contaminated with Respiratory Viruses During 1981-1986.- Eradication of Encephalitozoonosis in Rabbit Breeding Colonies by Carbon Immunoassay.- Spontaneous Murine Hemosiderosis, A Model for Human Hemochromatosis?.- In Vitro Adhesion of K88 Positive E. Coli to Intestinal Villi of Just-Weaned Piglets.- The Effects of Gentling on Open-Field Behaviour of Rats.- Blastomere-Karyotyping: A Direct Method for Producing Mouse Trisomy 16 ? Diploid Aggregation Chimeras as an Animal Model of Human Down's Syndrome.- A Proposed Species Difference in the Renal Excretion of Perfluoro Octanoic Acid in the Beagle Dog and Rat.- Measurement of Orthostatic Responses in Conscious Dogs.- Oral 65Zn Loading Test in Rats FED IRI-OB Diet with Various Zn Concentrations.- Mortality and Tumour Incidence of BDII/Han Rats.- Assessment of Discomfort Induced by Orbital Functure in Rats.- Effect of Morphinomimetics in Different Pain Tests.- Prevention of Early Deaths in Mice Contaminated with Gram Negative Enteric Bacteria and Fungus Following Irradiation.- Detection of Mycoplasma neurolyticum in a Colony of Inbred Mice: Clinically Silent Infection.- Effects ofHandling and Transportation Stress on Rodents.
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