New Influenza A (H1N1) Neuraminidase Inhibitory Curcuminoids - Bui Thanh, Tung
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The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. As part of an ongoing anti-influenza screening program of natural products, some curcuminoids were isolated from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2. Furthermore, they exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells.…mehr

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Produktbeschreibung
The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. As part of an ongoing anti-influenza screening program of natural products, some curcuminoids were isolated from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2. Furthermore, they exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. In addition, the detailed relationships of structure and activity by the compounds were investigated. These results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the battle against influenza A (H1N1).
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Autorenporträt
Bui Thanh Tung, is a Vietnamese researcher in pharmacology field. He got Master degree in Pharmacognosy in Chosun University, South Korea and completed his PhD in Seville University, Spain. His interests focus on natural product with strong anti-inflammation, antioxidant and antivirus activity. This book is based on his master dissertation in 2011.