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Pyridazine and pyrazole ring systems are known to possess potent biological and pharmacological properties. On the other hand some pyridazines derivatives are used as key starting material for the synthesis of commercial dyes. Acetylacetone, ethyl acetoacetate and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones, ethyl arylazoacetoacetates and arylazomalononitriles; these when refluxed with 5,6-diphenyl-2,3-dihydro-3-oxopyridazine-4-carbohydrazide, 3-amino-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and 3-hydrazino-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine…mehr

Produktbeschreibung
Pyridazine and pyrazole ring systems are known to possess potent biological and pharmacological properties. On the other hand some pyridazines derivatives are used as key starting material for the synthesis of commercial dyes. Acetylacetone, ethyl acetoacetate and malononitrile were coupled with diazotized arylamines to give arylazoacetylacetones, ethyl arylazoacetoacetates and arylazomalononitriles; these when refluxed with 5,6-diphenyl-2,3-dihydro-3-oxopyridazine-4-carbohydrazide, 3-amino-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine and 3-hydrazino-4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine yielded the corresponding 4-[(3-arylazo-3,5-dimethylpyrazol-1-yl)carbonyl]-5,6-diphenylpyridazin-3(2H)-one, 7-arylazo-6-methyl-3,4-diphenylpyrimido[1`,2`:1,5]pyrazole[3,4-c]pyridazin-8(5H)-one and 2-(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl)-4-arylazo-1,2-dihydro-5-methyl-3H-pyrazol-3-one dyes respectively. The dyes were applied to polyester and polyamide fabrics, and their spectral and fastness properties measured.
Autorenporträt
Dr. Abdelgawad is an Ass. Prof. in Jazan University, KSA. He completed his undergraduate studies in Chemistry at Zagazig University (Zagazig, Egypt, May 2002). August 2004, he won a scholarship from Academy of Scientific Research and Technology in Cairo. He obtained MSc in organic chemistry (2007), then PhD in natural products (2013) from ZU.