Xiangyu Chen

New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations

• Gebundenes Buch

Produktbeschreibung

This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and ,beta-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of beta-substituted nitroalkenes. The scope of Rauhut-Currier reaction was successfully extended to the most challenging beta-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via Gamma-addition. Highly enantiopure tetrahydropyridazinones and Gamma-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available ,beta-unsaturated carboxylic acids were first successfully employed to generate the ,beta-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer Nature Singapore / Springer, Berlin
• Artikelnr. des Verlages: 978-981-10-2898-4
• 1st ed. 2017
• Seitenzahl: 123
• Erscheinungstermin: 30. Dezember 2016
• Englisch
• Abmessung: 241mm x 159mm x 15mm
• Gewicht: 327g
• ISBN-13: 9789811028984
• ISBN-10: 9811028982
• Artikelnr.: 45752864

Inhaltsangabe

Introduction.- NHC-catalyzed Annulations of Nitroalkenes.- NHC-catalyzed Enantioselective Annulations of Enals.- NHC-catalyzed Enantioselective Annulations of ,beta-unsaturated Carboxylic Acids.- Experimental Part.- Research Summary.