New therapeutic compounds against tuberculosis - Al-Khafaji, Zahra Mahmoud
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Tuberculosis (TB) proved to be a controllable , preventable and curable disease , but it still remains as a leading cause for mortality. Rational Drug Design (RDD) is basically a computer-aided molecular modeling, it is an iterative process, If it is based on the knowledge of three - dimensional (3-D) structure of the target proteins of interest; it is called "structure based drug design" or "target based drug design". Such knowledge allows to design molecules capable of binding the receptor so as to maximize the drug affinity and specificity towards the target. Mycolic acid biosynthesis…mehr

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Produktbeschreibung
Tuberculosis (TB) proved to be a controllable , preventable and curable disease , but it still remains as a leading cause for mortality. Rational Drug Design (RDD) is basically a computer-aided molecular modeling, it is an iterative process, If it is based on the knowledge of three - dimensional (3-D) structure of the target proteins of interest; it is called "structure based drug design" or "target based drug design". Such knowledge allows to design molecules capable of binding the receptor so as to maximize the drug affinity and specificity towards the target. Mycolic acid biosynthesis pathway in Mycobacterium tuberculosis was considered a fatal target by designing inhibitors against the enzymes which play a vital role in this pathway.
Autorenporträt
Asra'a Adnan Abdul-Jalil , Ph.D. in Genetic engineering - minor specialization: Bioinformatics and in silico drug design- Baghdad university, lecturer at university of Anbar, ten years in the academic work, four published papers and twelve registered DNA sequences in GenBank database/NCBI for genes isolated from Iraqi strains.