Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. New York State Route 81 (NY 81) is an east west state highway in the Capital District of New York, United States. The western terminus of the route is at NY 145 in the hamlet of Cooksburg within the town of Rensselaerville. The eastern terminus is at U.S. Route 9W in the town of Coxsackie. East of US 9W, the right-of-way of NY 81 continues southeast to the village of Coxsackie as NY 385. NY 81 intersects NY 32 north of the hamlet of Cairo.