Applications in Medicine and the Pharmaceutical Industry Herausgegeben:Adetunji, Charles Oluwaseun; Oloke, Julius Kola; Dwivedi, Naveen; Ummalyma, Sabeela Beevi; Dwivedi, Shubha; Hefft, Daniel Ingo; Adetunji, Juliana Bunmi
Applications in Medicine and the Pharmaceutical Industry Herausgegeben:Adetunji, Charles Oluwaseun; Oloke, Julius Kola; Dwivedi, Naveen; Ummalyma, Sabeela Beevi; Dwivedi, Shubha; Hefft, Daniel Ingo; Adetunji, Juliana Bunmi
NEXT-GENERATION ALGAE The book comprehensively details the novel and biologically active compounds derived from algae for sustainable healthcare delivery that could be used for the treatment of an ever-increasing population, prevention of high rate of morbidity rates, as well as in the treatment of numerous diseases, and serve as an alternative drug for the prevention of high level of resistance to synthetic drugs. This second volume places a special emphasis on the discovery of novel and biologically active compounds from algae. It covers a wide range of applications, including the use…mehr
The book comprehensively details the novel and biologically active compounds derived from algae for sustainable healthcare delivery that could be used for the treatment of an ever-increasing population, prevention of high rate of morbidity rates, as well as in the treatment of numerous diseases, and serve as an alternative drug for the prevention of high level of resistance to synthetic drugs.
This second volume places a special emphasis on the discovery of novel and biologically active compounds from algae. It covers a wide range of applications, including the use of astaxanthin and carotenoids derived from algae for the production of nutraceuticals, pharmaceuticals, additives, food supplements, and feed. The book also discusses the production of polyunsaturated fatty acids (PUFAs) and their biomedical applications, recent advancements in the research of sulfated polysaccharides from algal origin, and their antiulcer bioactivities. Other topics include the application of algae in wound healing, the use of nanotechnology for the bioengineering of useful metabolites derived from algae and their multifaceted applications, and the production of single-cell proteins and pigments with high relevance in the industry.
Audience
Researchers in industry and academia as well as clinicians in the fields of microbiology, biotechnology, and food science will find this book very pertinent.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Charles Oluwaseun Adetunji, PhD, is an associate professor in the Microbiology Department, Edo University Iyamho, Nigeria. He has filed several scientific patents and has published over 180 scientific journal articles, books, and conference proceedings. He has received numerous awards from international organizations. Julius Kola Oloke, PhD, is the Vice Chancellor of Precious Cornerstone University, Ibadan, Oyo State, Nigeria. Naveen Dwivedi, PhD, is an associate professor in the Department of Biotechnology at the S. D. College of Engineering and Technology, Muzaffarnagar, Uttar Pradesh, India. Sabeela Beevi Ummalyma, PhD, is a scientist at the Institute of Bioresources and Sustainable Development, Bioenergy and Bioprocessing laboratory Sikkim Centre, Sikkim, India. Shubha Dwivedi, PhD, is an associate professor in the Department of Biotechnology, IIMT University, Meerut, UP, India. Daniel Hefft, PhD, is a chemical and food engineer and is the Product Research Team Lead at Campden BRI, UK. This role within the consulting technology department delivers meaningful contract R&D and process engineering solutions. Juliana Bunmi Adetunji, PhD, is a faculty member in the Department of Biochemistry, Osun State University, Osogbo, Nigeria. Her research interests are focused on the nutritional safety of foods and the evaluation of medicinal plants in the management and maintenance of human health.
Inhaltsangabe
Preface xv
1 Discovery of Novel and Biologically Active Compounds from Algae 1 M. Singh, N. Gupta, P. Gupta, Doli, P. Mishra and A. Yadav
1.1 Introduction 2
1.2 Microalgae-Derived Natural Products 3
1.3 Bioprospecting for New Algae 4
1.4 Therapeutically Essential Natural Products 6
1.5 Screening for Bioactive Constituents 7
1.6 Extraction Methods 9
1.7 Biosynthesis and Biological Activities 11
1.7.1 Antibacterial Action 15
1.7.2 Antifungal Action 17
1.7.3 Anti-Inflammatory Action 18
1.7.4 Antiprotozoal Action 19
1.7.5 Antioxidant Action 20
1.7.6 Antineoplastic (Anticancer) Action 21
1.7.7 Antiviral Action 24
1.7.8 Anticoagulant Action 25
1.7.9 Immunosuppressive Action 25
1.8 Conclusion 26
References 27
2 Bioactive Compounds Synthesized by Algae: Current Development and Prospects as Biomedical Application in the Pharmaceutical Industry 41 Preeti Mishra, Namrata Gupta, Monika Singh and Deeksha Tiwari
2.1 Introduction 42
2.2 Algal-Sourced Compounds of Medical Interest 43
2.3 Microalgae with Potential for Obtaining Bioactive Compounds 44
2.3.1 Spirulina 46
2.3.2 Chlorella 47
2.3.3 Nostoc 49
2.3.4 Dunaliella 50
2.4 Bioactive Compounds from Cyanobacteria 51
2.5 Secondary Metabolites from Microalgae 55
2.5.1 Carotenoids 55
2.5.1.1 ß-Carotene 55
2.5.1.2 Astaxanthin 57
2.5.1.3 Zeaxanthin and Lutein 58
2.5.1.4 Violaxanthin 59
2.5.1.5 Fucoxanthin 59
2.5.2 Polyunsaturated Fatty Acids 60
2.5.3 Proteins and Polypeptides 61
2.6 Biomass of Microalgae 62
2.6.1 Biomass Production 62
2.6.1.1 Cultivation 62
2.6.1.2 Harvesting 63
2.6.1.3 Biomass Dehydration 64
2.6.1.4 Extraction of Bioactive Compounds 66
2.7 Pharmaceutical Applications of Microalgae 66
2.8 Conclusion 71
References 72
3 Bioactive Compounds Derived from Microalgae Showing Diverse Medicinal Activities 77 D. Tiwari, P. Mishra and N. Gupta
3.1 Introduction 78
3.2 Microalgae with Anti-Inflammatory Activity 81
3.3 Microalgae with Immunomodulatory Activity 82
3.4 Microalgae Anticancer Activity 85
3.5 Potential of Microalgae in Quality Enhancement of Natural Products 87
3.5.1 Pharmaceutical Industry 87
3.5.2 Cosmetics and Personal Care 87
3.5.3 Food Industry 88
References 90
4 Application of Astaxanthin and Carotenoids Derived from Algae for the Production of Nutraceuticals, Pharmaceuticals, Additives, Food Supplement and Feed 95 Abiola Folakemi Olaniran, Joshua Opeyemi Folorunsho, Bolanle Adenike Akinsanola, Abiola Ezekiel Taiwo, Yetunde Mary Iranloye, Clinton Emeka Okonkwo and Omorefosa Osarenkhoe Osemwegie
4.1 Carotenoids and Its Characteristics 96
4.1.1 Sources of Carotenoids 97
4.1.2 Production/Extraction of Carotenoids 99
4.2 Astaxanthin and Its Characteristics 102
4.2.1 Production/Extraction of Astaxanthin 103
4.2.2 Historical Perspective of Consumption of Alga as Food and Utilization in the Food Industry 104
4.3 Application/Utilization of Astaxanthin and Carotenoids in Different Sectors 105
4.3.1 Nutraceuticals 108
4.3.2 Food Additives, Supplements and Feed Formulation 110
4.3.3 Alga as a Potential Source of Astaxanthin and Food Supplement 111
4.3.4 Technological Application of Algae as Origins of Suppl
1 Discovery of Novel and Biologically Active Compounds from Algae 1 M. Singh, N. Gupta, P. Gupta, Doli, P. Mishra and A. Yadav
1.1 Introduction 2
1.2 Microalgae-Derived Natural Products 3
1.3 Bioprospecting for New Algae 4
1.4 Therapeutically Essential Natural Products 6
1.5 Screening for Bioactive Constituents 7
1.6 Extraction Methods 9
1.7 Biosynthesis and Biological Activities 11
1.7.1 Antibacterial Action 15
1.7.2 Antifungal Action 17
1.7.3 Anti-Inflammatory Action 18
1.7.4 Antiprotozoal Action 19
1.7.5 Antioxidant Action 20
1.7.6 Antineoplastic (Anticancer) Action 21
1.7.7 Antiviral Action 24
1.7.8 Anticoagulant Action 25
1.7.9 Immunosuppressive Action 25
1.8 Conclusion 26
References 27
2 Bioactive Compounds Synthesized by Algae: Current Development and Prospects as Biomedical Application in the Pharmaceutical Industry 41 Preeti Mishra, Namrata Gupta, Monika Singh and Deeksha Tiwari
2.1 Introduction 42
2.2 Algal-Sourced Compounds of Medical Interest 43
2.3 Microalgae with Potential for Obtaining Bioactive Compounds 44
2.3.1 Spirulina 46
2.3.2 Chlorella 47
2.3.3 Nostoc 49
2.3.4 Dunaliella 50
2.4 Bioactive Compounds from Cyanobacteria 51
2.5 Secondary Metabolites from Microalgae 55
2.5.1 Carotenoids 55
2.5.1.1 ß-Carotene 55
2.5.1.2 Astaxanthin 57
2.5.1.3 Zeaxanthin and Lutein 58
2.5.1.4 Violaxanthin 59
2.5.1.5 Fucoxanthin 59
2.5.2 Polyunsaturated Fatty Acids 60
2.5.3 Proteins and Polypeptides 61
2.6 Biomass of Microalgae 62
2.6.1 Biomass Production 62
2.6.1.1 Cultivation 62
2.6.1.2 Harvesting 63
2.6.1.3 Biomass Dehydration 64
2.6.1.4 Extraction of Bioactive Compounds 66
2.7 Pharmaceutical Applications of Microalgae 66
2.8 Conclusion 71
References 72
3 Bioactive Compounds Derived from Microalgae Showing Diverse Medicinal Activities 77 D. Tiwari, P. Mishra and N. Gupta
3.1 Introduction 78
3.2 Microalgae with Anti-Inflammatory Activity 81
3.3 Microalgae with Immunomodulatory Activity 82
3.4 Microalgae Anticancer Activity 85
3.5 Potential of Microalgae in Quality Enhancement of Natural Products 87
3.5.1 Pharmaceutical Industry 87
3.5.2 Cosmetics and Personal Care 87
3.5.3 Food Industry 88
References 90
4 Application of Astaxanthin and Carotenoids Derived from Algae for the Production of Nutraceuticals, Pharmaceuticals, Additives, Food Supplement and Feed 95 Abiola Folakemi Olaniran, Joshua Opeyemi Folorunsho, Bolanle Adenike Akinsanola, Abiola Ezekiel Taiwo, Yetunde Mary Iranloye, Clinton Emeka Okonkwo and Omorefosa Osarenkhoe Osemwegie
4.1 Carotenoids and Its Characteristics 96
4.1.1 Sources of Carotenoids 97
4.1.2 Production/Extraction of Carotenoids 99
4.2 Astaxanthin and Its Characteristics 102
4.2.1 Production/Extraction of Astaxanthin 103
4.2.2 Historical Perspective of Consumption of Alga as Food and Utilization in the Food Industry 104
4.3 Application/Utilization of Astaxanthin and Carotenoids in Different Sectors 105
4.3.1 Nutraceuticals 108
4.3.2 Food Additives, Supplements and Feed Formulation 110
4.3.3 Alga as a Potential Source of Astaxanthin and Food Supplement 111
4.3.4 Technological Application of Algae as Origins of Suppl
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