NF-kB in Health and Disease

Herausgegeben:Karin, Michael

• Gebundenes Buch

Produktbeschreibung

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology-from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

Produktdetails

• Current Topics in Microbiology and Immunology 349
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 80020230, 978-3-642-16016-5
• 2011
• Seitenzahl: 276
• Erscheinungstermin: 6. Mai 2011
• Englisch
• Abmessung: 241mm x 160mm x 20mm
• Gewicht: 582g
• ISBN-13: 9783642160165
• ISBN-10: 3642160166
• Artikelnr.: 31560472

Inhaltsangabe

Preface.- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms.- IKK regulation and human genetics.- Specialized chromatin patterns in the control of inflammatory gene expression.- Macrophages and NF-kappaB in Cancer.- NF- B/Rel proteins and the humoral immune responses of Drosophila melanogaster.- IKK and NF-kappaB mediated functions in carcinogenesis.- Control of NF-kappaB activity by proteolysis.- NF-kappaB as a target for oncogenic viruses.- NF-kappaB and Innate Immunity.- Inhibition of NF-kappaB signaling as a strategy in disease therapy.- NF- B and mucosal homeostasis.- NF-kappaB In liver cancer - the plot thickens.- Subject index.