High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! Nicholas County is a county located in the U.S. state of Kentucky. As of 2000, the population was 6,813. Its county seat is Carlisle. The county is named for George Nicholas, the "Father of the Kentucky Constitution". According to the U.S. Census Bureau, the county has a total area of 197 square miles (510 km2), essentially all of which is land.