NKX-Homeodomain Factor
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High Quality Content by WIKIPEDIA articles! A homeobox is about 180 base pairs long. It encodes a protein domain (the homeodomain) which when expressed (e.g. as protein) can bind DNA. The consensus 60-polypeptide chain corresponding to homeobox domain is, with typical intron positions noted with dashes: RRRKRTA-YTRYQLLE-LEKEFLF-NRYLTRRRRIELAHSL-NLTERHIKIWFQN-RRMK-WKKEN Homeobox genes encode transcription factors that typically switch on cascades of other genes. The homeodomain binds DNA in a sequence-specific manner. However, the specificity of a single homeodomain protein is usually not…mehr

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High Quality Content by WIKIPEDIA articles! A homeobox is about 180 base pairs long. It encodes a protein domain (the homeodomain) which when expressed (e.g. as protein) can bind DNA. The consensus 60-polypeptide chain corresponding to homeobox domain is, with typical intron positions noted with dashes: RRRKRTA-YTRYQLLE-LEKEFLF-NRYLTRRRRIELAHSL-NLTERHIKIWFQN-RRMK-WKKEN Homeobox genes encode transcription factors that typically switch on cascades of other genes. The homeodomain binds DNA in a sequence-specific manner. However, the specificity of a single homeodomain protein is usually not enough to recognize only its desired target genes. Most of the time, homeodomain proteins act in the promoter region of their target genes as complexes with other transcription factors. Such complexes have a much higher target specificity than a single homeodomain protein.