Shareefa AlGhamdi

Non-alcoholic fatty liver disease and drug toxicity

• Broschiertes Buch

Produktbeschreibung

Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid in liver. Liver is the principal organ involved in drug biotransformation. The central hypothesis of this project is that alterations in the liver environment due to lipid accumulation aggravate sensitivity of hepatocytes to toxicity of some commonly prescribed drugs (paracetamol, alcohol, phenobarbital, cisplatin or doxorubicin). The aim of this study was to investigate the effect of lipid overloading (steatosis) on drug cytotoxicity in the liver model Huh7 cell line.The microarray data confirmed alterations in oxidative stress-related genes. Such changes were functionally relevant as confirmed by cellular assay and In-Cell Western blot. In conclusion, the hypothesised effect of steatosis on drug toxicity has been confirmed and steatosis may enhance drug toxicity through changing cellular oxidative state and activating the apoptotic pathway.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 352
• Erscheinungstermin: 30. November 2015
• Englisch
• Abmessung: 220mm x 150mm x 22mm
• Gewicht: 542g
• ISBN-13: 9783659807138
• ISBN-10: 3659807133
• Artikelnr.: 44376949

Autorenporträt

2015-Present: Assistant professor-Department of Biochemistry-Faculty of Science-King Abdulaziz University.2010-2015: Lecturer-Department of Biochemistry-Faculty of Science-King Abdulaziz University2011-2015: PhD student-University of Surrey-UK2007- 2010: Demonstrator- Department of Biochemistry-Faculty of Science-King Abdulaziz University