Norfenfluramine
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Norfenfluramine (3-Trifluoromethylamphetamine) is a psychoactive drug which functions as a serotonin releasing agent and potent 5HT2B receptor agonist. The action of norfenfluramine on 5HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic drug, as it forms norfenfluramine…mehr

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Norfenfluramine (3-Trifluoromethylamphetamine) is a psychoactive drug which functions as a serotonin releasing agent and potent 5HT2B receptor agonist. The action of norfenfluramine on 5HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. This side effect led to the withdrawal of fenfluramine as an anorectic drug, as it forms norfenfluramine as a metabolite. Norfenfluramine has also been shown to be vasoactive in its own right, causing pulmonary hypertension.