Regeneration:- The richest of resources in nature, lie in the nature itself! Human mouth benefits from remarkable properties, it is very susceptible to traumatic injuries, exposure to microbial attacks, and congenital abnormalities. As the human dentition plays a crucial role in mastication, speech as well as esthetics, searching definite and more effective strategies to reestablish the functionality in the event of disruption has been important. Extensive developments in the field of stem cell and tissue engineering techniques along their applications have made the application of the regenerative medicine field to dentistry possible. Recent progress and evolution has magnified the clinical relevance of this emerging field in dentistry as a feasible restorative option for replacement and regeneration of dental tissues. Regenerative endodontics is an inevitable therapy and call for action. The unleashed potential of regenerative endodontics may benefit millions of patient in each year.