Kenichi Sakai (Volume ed.) / Noriaki Hirayama / Rui Tamura

Novel Optical Resolution Technologies

Herausgegeben:Sakai, Kenichi; Hirayama, Noriaki; Tamura, Rui

• Gebundenes Buch

Produktbeschreibung

After theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capableofresolvingthesurface as wellas theinsidestructureofcrystalsattheatomiclevelwhilenewhigh-performance computingresourcesaffordthecapabilityofmodelingthecomplexlarge-scale alignmentsnecessarytosimulatecrystallizationinrealsystems.Asaresult,the science of crystallization has shifted gradually fromstatic to dynamic science and considerable progress now underlies the complex but beautiful cryst- lization process. I believe that if a de?nitive history of 21st century science is ever written,one of the highlightswill be the science ofcrystallization. This science has the following characteristics: in?nite advances in soph- tication, unlimited opportunities not only for intellectual excitement but also forindustrialmerit,strongcollaborationwithbiologyandmaterialscience,as wellaswithallareasofchemistry.Thevastpotentialofcrystallizationasan- portant?eld ofscience isfar beyondthesimple technologyofpharmaceutical industries during the 20th century. Optical resolution was one small area of chemistry in the last century. This was more a technology than a science, largely because trial and error was the only method to obtain good results. However, the situation is now changing. Therearesomanyappealing,hidden?ndingsintheprocessofcrystallization. Historically, crystallization began in an old laboratory in academia and then gradually shifted to industry. Now,it is making itscomeback in academia due toseveralnewresearchbranchestryingtodiscoverwhatisgoingonduringthe crystallizationprocess.Ibelieve this?eld ofscience isnowgrowingasa result of the wonderfulcoupling between industry and academia. I read a prepublication draft of Novel Optical Resolution Technologies,and foundthateachoneofthesegeneralcharacteristicsofsciencehadarealityand sharpness that I had not expected. While it was a sheer delight to revisit each of these triumphs guided by the wise insights and analyses found throughout the book. There is a good balance between the underlying historical material and the design and execution aspects of each topic.

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Produktdetails

• Topics in Current Chemistry 269
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 11514619, 978-3-540-46317-7
• 2007
• Seitenzahl: 328
• Erscheinungstermin: 15. Februar 2007
• Englisch
• Abmessung: 241mm x 160mm x 24mm
• Gewicht: 670g
• ISBN-13: 9783540463177
• ISBN-10: 3540463178
• Artikelnr.: 20946540

Autorenporträt

Kenichi Sakai, Toray Fine Chemicals, Tokyo, Japan / Noriaki Hirayama, Tokai University, Tokyo, Japan / Rui Tamura, Kyoto University, Kyoto, Japan

Inhaltsangabe

Preferential Crystallization.- Mechanism and Scope of Preferential Enrichment, a Symmetry-Breaking Enantiomeric Resolution Phenomenon.- Racemization, Optical Resolution and Crystallization-Induced Asymmetric Transformation of Amino Acids and Pharmaceutical Intermediates.- Advantages of Structural Similaritiesof the Reactants in Optical Resolution Processes.- Dutch Resolution of Racemates and the Roles of Solid Solution Formation and Nucleation Inhibition.- New Resolution Technologies Controlled by Chiral Discrimination Mechanisms.- Molecular Mechanisms of Dielectrically Controlled Resolution (DCR).- From Racemates to Single Enantiomers - Chiral Synthetic Drugs over the last 20 Years.