Novel protein-protein interactions in brain - Kantamneni, Sriharsha
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Dynamic functioning of neurons in the brain depends on the receiving and relay of a co-ordinated balance of excitatory and inhibitory signals. Disturbance of this balance at least in part can be attributed, to many types of brain disorders and degenerative diseases. Most excitatory signals that a neuron receives are mediated via proteins called glutamate receptors whereas most inhibitory signals are mediated via proteins called Gamma-amino butyric acid (GABA) receptors. Many factors influence the balance of excitatory and inhibitory input on any given neuron. One important consideration is the…mehr

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Produktbeschreibung
Dynamic functioning of neurons in the brain depends on the receiving and relay of a co-ordinated balance of excitatory and inhibitory signals. Disturbance of this balance at least in part can be attributed, to many types of brain disorders and degenerative diseases. Most excitatory signals that a neuron receives are mediated via proteins called glutamate receptors whereas most inhibitory signals are mediated via proteins called Gamma-amino butyric acid (GABA) receptors. Many factors influence the balance of excitatory and inhibitory input on any given neuron. One important consideration is the number and type of receptors present at the correct location to receive signals. Thus the mechanisms that regulate the transport and anchoring of receptors at a particular site are of considerable importance. The work here aims to understand the role of a newly discovered protein we have called GISP that binds to GABA subtype B1 receptors and is likely to be involved in these processes.
Autorenporträt
Dr. Sriharsha Kantamneni has obtained his PhD in Neuroscience in 2005 from University of Bristol, UK. He has been working on the synthesis, distribution, trafficking,regulation and post-translational modification of amino acid receptors in brain. He is the author of several scientific articles published in peer-reviewed international journals.