In this project I tried to make some substituted Phenyl and Alkyl moieties of Pyrazole to get more effects of antimicrobial activities. In reference of these derivatives I.R., N.M.R., Mass and Antimicrobial tests have been occured. In these tests I got more effective results of various derivatives of Pyrazole then normal Pyrazole compound. All Instrumental data shows high impact of derivatives in rising of molecule and group numbers.