Andy Yi-an Shih

Nrf2 as a Therapeutic Target for Stroke and Neurodegeneration

• Broschiertes Buch

Produktbeschreibung

Stroke is a leading cause of death and disability in
North America.
One major cause of nerve tissue damage during stroke
is the
accumulation of reactive oxygen species- molecules
that steal
electrons from healthy cells in a process known as
oxidation. This
thesis describes a novel approach to increase
antioxidant levels in
order to maintain oxidative balance and prevent
cellular damage
during stroke. The stress-responsive transcription
factor, Nrf2, is
able to launch the endogenous mechanisms of cellular
defense and
repair. Nrf2 represents a master switch that
coordinates tens to
hundreds of antioxidant and detoxification genes
working in
synergy. In rodent models of stroke and
neurodegeneration,
increased Nrf2 activity was found to promote neuronal
survival and
improve recovery of limb function weeks to months
following injury.
Interestingly, a number of molecules that activate
Nrf2 are found in
cruciferous vegetables, such as broccoli sprouts,
suggesting the
possibility of practical diet-based therapies.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 240
• Englisch
• Abmessung: 220mm x 150mm x 14mm
• Gewicht: 376g
• ISBN-13: 9783639142266
• ISBN-10: 3639142268
• Artikelnr.: 26182238

Autorenporträt

Andy received his Ph.D. in Neuroscience at the University of
British Columbia with
Dr. Tim Murphy. He is currently working as a post-doctoral fellow
with Dr. David
Kleinfeld at the University of California, San Diego. His present
research uses novel
imaging techniques to study reactivity of arterioles in the
rodent brain.