Nrf2 as a Therapeutic Target for Stroke and Neurodegeneration
Andy Yi-an Shih
Broschiertes Buch

Nrf2 as a Therapeutic Target for Stroke and Neurodegeneration

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Stroke is a leading cause of death and disability inNorth America. One major cause of nerve tissue damage during strokeis the accumulation of reactive oxygen species- moleculesthat steal electrons from healthy cells in a process known asoxidation. This thesis describes a novel approach to increaseantioxidant levels in order to maintain oxidative balance and preventcellular damage during stroke. The stress-responsive transcriptionfactor, Nrf2, is able to launch the endogenous mechanisms of cellulardefense and repair. Nrf2 represents a master switch thatcoordinates tens to hundreds of antioxidan...