Andere Kunden interessierten sich auch für
![Gut microorganisms in sugarcane pests]( "Gut microorganisms in sugarcane pests")
Gut microorganisms in sugarcane pests36,99 €![Blueberry on the Bacteria Flora of the Gut With Ref. to Lactobacillus]( "Blueberry on the Bacteria Flora of the Gut With Ref. to Lactobacillus")
Blueberry on the Bacteria Flora of the Gut With Ref. to Lactobacillus32,99 €![Bacteroidetes In the Gut Flora of Lean & Obese Patients]( "Bacteroidetes In the Gut Flora of Lean & Obese Patients")
Bacteroidetes In the Gut Flora of Lean & Obese Patients32,99 €![Gut E.coli Induce Colon Cancer & E.coli K1 Cause Apoptosis In Gut Cell]( "Gut E.coli Induce Colon Cancer & E.coli K1 Cause Apoptosis In Gut Cell")
Gut E.coli Induce Colon Cancer & E.coli K1 Cause Apoptosis In Gut Cell23,99 €![Bioinformatics approaches for the study of the human gut microbiome]( "Bioinformatics approaches for the study of the human gut microbiome")
Bioinformatics approaches for the study of the human gut microbiome36,99 €![Probiotics as Live Biotherapeutics for Veterinary and Human Health, Volume 2]( "Probiotics as Live Biotherapeutics for Veterinary and Human Health, Volume 2")
Probiotics as Live Biotherapeutics for Veterinary and Human Health, Volume 2148,99 €![How Fermented Foods Feed a Healthy Gut Microbiota]( "How Fermented Foods Feed a Healthy Gut Microbiota")
How Fermented Foods Feed a Healthy Gut Microbiota110,99 €
Understanding the physiology of bacterial pathogens is essential to design more effective therapies. Thus the biochemical and molecular characteristics of aspartate carbamoyltransferase, the first step in pyrimidine biosynthesis, was investigated in the human pathogen Helicobacter pylori. Using enzymatic analysis procedures including NMR spectroscopy and radioactive tracer analysis, the regulatory properties of H. pylori ACTase were determined. The results indicated that the first step in this pathway of H. pylori was highly regulated. To determine whether ACTase plays an essential role in cell survival in H. pylori, an attempt was made to construct a mutant deficient in this enzyme activity. However, no mutants were isolated. These findings suggest ACTase is essential for survival of H. pylori. As ACTase appeared to be a potential therapeutic target, the effects of PALA, a potent inhibitor of this enzyme, was tested on cell viability. However, PALA had no effect on the viabilityof the cells. The results suggested H. pylori transformed the inhibitor into non-cytotoxic products, thus providing the bacterium with a mechanism of resistance that appears unique.