Heino Prinz

Numerical Methods for the Life Scientist

Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB

• Broschiertes Buch

Produktbeschreibung

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

Produktdetails

• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-662-50587-8
• Softcover reprint of the original 1st ed. 2011
• Seitenzahl: 160
• Erscheinungstermin: 23. August 2016
• Englisch
• Abmessung: 235mm x 155mm x 9mm
• Gewicht: 256g
• ISBN-13: 9783662505878
• ISBN-10: 3662505878
• Artikelnr.: 48938323

Inhaltsangabe

Preparing the computer.- Binding equilibria.- Binding kinetics.- Least squares fit to experimental data.- Multi-parameter fits.- Comparing the two different approaches.